{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:28:24Z","timestamp":1747182504870,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":67,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900511"],"award-info":[{"award-number":["81900511"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Variceal hemorrhage is a fatal complication of cirrhosis. In this study, we aimed to investigate the role of serum interleukin 2 receptor (sIL\u20102R) as a predictive indicator in patients with a previous history of cirrhosis\u2010related variceal bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 340 cirrhotic patients who had experienced variceal bleeding from December 2016 to December 2018 were enrolled, and were randomly assigned to the modeling group and the validation group. The 3\u2010year variceal rebleeding rate and other outcomes including adverse events were analyzed between patients with different sIL\u20102R levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A time\u2010dependent receiver operating characteristic (ROC) curve of variceal rebleeding indicated that sIL\u20102R had an area under the ROC curve (AUROC] of 0.731 and 0.837 for the modeling and validation groups, respectively, with a cut\u2010off value of 426\u2009U\/mL. Kaplan\u2013Meier analysis showed that higher sIL\u20102R level was related to an increased risk of variceal rebleeding rate (55.33% vs 24.34%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.024 and 51.28% vs 15.32%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.049) and decreased 3\u2010year survival rate (91.16% vs 98.92%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.013 and 90.52% vs 97.50%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.180) in the modeling and validation groups. Elevated sIL\u20102R levels were associated with an increased risk of portal vein thrombosis and severe ascites as well as inferior liver function, hypercoagulable state, and increased portal pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High sIL\u20102R levels were associated with poor prognosis in cirrhotic patients with previous variceal bleeding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13141","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T11:20:19Z","timestamp":1666869619000},"page":"577-586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic importance of interleukin 2 receptor for patients with a history of cirrhotic variceal bleeding"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2944-0750","authenticated-orcid":false,"given":"Si Yu","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Quan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Yuan","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying 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