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Cox regression analysis was used to investigate the association between systemic inflammatory biomarkers and 90\u2010day liver transplant (LT)\u2010free mortality. A generalized additive model (GAM) was used to illustrate the quantitative curve relationship between NLR and 90\u2010day LT\u2010free mortality. Kaplan\u2013Meier method was used to estimate the 90\u2010year LT\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of CSH was 20.5% (226\/1103). The 28\u2010day and 90\u2010day LT\u2010free mortality rates were 17.7% and 26.1%, respectively, for patients with non\u2010cirrhotic\u00a0CSH. Patients with no infection accounted for 75.0% of all CSH patients, and NLR was independently associated with 90\u2010day LT\u2010free mortality. NLR of 2.9 might be related to disease deterioration in CSH patients without infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NLR may be an independent risk factor for 90\u2010day LT\u2010free mortality in patients with non\u2010cirrhotic chronic liver disease. A NLR of 2.9 as the cut\u2010off value can be used to predict disease aggravation in CSH patients without infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13143","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T15:40:04Z","timestamp":1667490004000},"page":"587-596","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The neutrophil\u2010to\u2010lymphocyte ratio represents a systemic inflammation marker and reflects the relationship with 90\u2010day mortality in non\u2010cirrhotic chronic severe hepatitis"],"prefix":"10.1111","volume":"23","author":[{"given":"Fu Chen","family":"Dong","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Key Laboratory of Gastroenterology and Hepatology, Chinese Ministry of Health (Shanghai Jiao Tong University), Renji Hospital School of Medicine, Shanghai Jiao Tong 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