{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:28:28Z","timestamp":1747182508964,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:00:00Z","timestamp":1680566400000},"content-version":"vor","delay-in-days":93,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130018"],"award-info":[{"award-number":["82130018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>In this study we aimed to assess the clinicopathological characteristics and long\u2010term prognosis of patients with nonalcoholic fatty liver disease (NAFLD) having distinct steatosis distribution patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinicopathological data of 238 individuals with biopsy\u2010confirmed NAFLD were collected. Nonalcoholic steatohepatitis\u2010clinical research network (NASH\u2010CRN) and steatosis, activity and fibrosis (SAF)\/fatty liver inhibition of progression (FLIP) algorithm were used. Cumulative incidence of liver\u2010related events (LREs) was compared by Kaplan\u2013Meier analysis. Univariate and multivariate logistic regression analyses were used to identify independent predictors for steatosis distribution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eligible patients were categorized into three groups based on their steatosis distribution, including azonal steatosis (AS) (62 [26.1%]), perivenular steatosis (PVS) (147 [61.8%]), and the pan\u2010acinar steatosis (PAS) groups (29 [12.1%]). There were significantly higher ballooning grade and disease activity (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), more severe fibrosis (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and a higher cumulative incidence of LREs (hazard ratio [HR] 8.0, 95% confidence interval [CI] 2.34\u201327.35, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) in the AS group than in the PVS and PAS groups after a median of 3.6\u2010year follow\u2010up. Multivariate logistic regression analysis revealed age (odds ratio [OR] 1.11, 95% CI 1.06\u20131.16, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) might be independently associated with AS distribution, and <jats:italic>PNPLA3<\/jats:italic> rs738409 CG\/GG genotype (OR 3.36, 95% CI 0.98\u201311.47, <jats:italic>P<\/jats:italic>\u2009=\u20090.053) might also play a role.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AS is associated with more severe disease activity and fibrosis stage in NAFLD, and predisposes toward poor prognosis. Age might be an independent predictor for AS in NAFLD, while <jats:italic>PNPLA3<\/jats:italic> rs738409 CG\/GG genotype might also play a role.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13163","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T06:09:41Z","timestamp":1678687781000},"page":"28-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Azonal steatosis correlates with disease severity and poor outcome of nonalcoholic fatty liver disease"],"prefix":"10.1111","volume":"24","author":[{"given":"Xiao Fei","family":"Tong","sequence":"first","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases Capital Medical University  Beijing 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Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and EBM Unit, National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Ning","family":"Wu","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing Jie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng Zhao","family":"Lu","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Juan","family":"Ou","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Dong","family":"Jia","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases Capital Medical University  Beijing 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