{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:44:51Z","timestamp":1784346291388,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T00:00:00Z","timestamp":1682121600000},"content-version":"vor","delay-in-days":111,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770538"],"award-info":[{"award-number":["81770538"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070551"],"award-info":[{"award-number":["82070551"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to evaluate the efficacy and safety of vonoprazan (VPZ) versus proton pump inhibitor (PPI) in clarithromycin\u2010based bismuth\u2010containing quadruple therapy (C\u2010BQT) for the treatment of <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) eradication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of patients in whom <jats:italic>H. pylori<\/jats:italic> was eradicated between 1 July 2018 and 31 December 2021 were retrieved retrospectively from the Outpatient Unit of Qilu Hospital. Efficacy, safety, and compliance were compared between VPZ\u2010based and PPI\u2010based C\u2010BQT, containing vonoprazan 20\u2009mg or proton pump inhibitors (lansoprazole 30\u2009mg or esomeprazole 20\u2009mg), bismuth 220 or 200 mg, amoxicillin 1000\u2009mg, and clarithromycin 500\u2009mg, twice daily for 2\u2009weeks by 1:1 propensity score matching analysis. The trial was registed on ClinicalTrials.gov (registration no. NCT05301725).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:italic>H. pylori<\/jats:italic> eradication rates of VPZ\u2010based and PPI\u2010based therapies were 88.8% (151\/170) and 87.6% (149\/170) in the intention\u2010to\u2010treat analysis, 94.1% (144\/153) and 91.1% (144\/158) in the per\u2010protocol analysis, respectively. The noninferiority of VPZ to PPI was confirmed in all analyses (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The incidence of adverse events was 30.0% (51\/170) and 27.1% (46\/170) in the VPZ\u2010based and PPI\u2010based groups, respectively. VPZ\u2010based and PPI\u2010based therapies were well tolerated and showed good patient compliance without significant differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>VPZ\u2010based therapy resulted in a satisfactory eradication rate and was well tolerated for <jats:italic>H. pylori<\/jats:italic> eradication, which are comparable to PPIs in C\u2010BQT as a first\u2010line treatment for <jats:italic>H. pylori<\/jats:italic> infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13166","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T06:36:08Z","timestamp":1679639768000},"page":"19-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Vonoprazan is noninferior to proton pump inhibitors in bismuth\u2010containing quadruple therapy for the treatment of <i>Helicobacter pylori<\/i> infection: A propensity score matching analysis"],"prefix":"10.1111","volume":"24","author":[{"given":"Juan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7042-9695","authenticated-orcid":false,"given":"Yue Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Juan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Shen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan 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