{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:02:07Z","timestamp":1779364927693,"version":"3.53.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":93,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We followed The Cancer Genome Atlas (TCGA) grouping criteria and conducted a clinicopathological cohort study in a unique patient population to gain insight into the pathobiology of esophageal adenocarcinoma (EAC) and adenocarcinoma of the gastroesophageal junction (AGEJ).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied and statistically compared the clinicopathological and prognostic features of both cancers in 303 consecutive patients treated at the Veterans Affairs Boston Healthcare System over a 20\u2010year period using uniform criteria and standardized routines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over 99% of patients were white men with a mean age of 69.1\u2009years and an average body mass index (BMI) of 28.0 kg\/m<jats:sup>2<\/jats:sup>. No significant differences were detected in age, gender, ethnicity, BMI, and history of tobacco abuse between the two groups. Compared to AGEJ patients, a significantly higher proportion of EAC patients had gastroesophageal reflux disease, long\u2010segment Barrett's esophagus, common adenocarcinoma type, smaller tumor size, better differentiation, more stages I or II but fewer stages III or IV diseases, scarcer lymph node invasion, fewer distant metastases, and better overall, disease\u2010free, and relapse\u2010free survival. The 5\u2010year overall survival rate was significantly higher in EAC patients than in AGEJ patients (41.3% vs 17.2%, <jats:italic>P<\/jats:italic> &lt;\u20090.001). This improved survival among EAC patients remained significant after censoring all cases detected during endoscopic surveillance, suggesting different pathogenesis mechanisms between EAC and AGEJ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EAC patients showed significantly better outcomes than AGEJ patients. Our results require validation in other patient populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13167","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T07:13:39Z","timestamp":1679901219000},"page":"98-112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Patients with esophageal adenocarcinoma showed better prognosis than those with adenocarcinoma of the gastroesophageal junction"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8963-834X","authenticated-orcid":false,"given":"Qin","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pathology Beth Israel Deaconess Medical Center and Harvard Medical School  Boston Massachusetts USA"},{"name":"Previously at the Department of Pathology and Laboratory Medicine Veterans Affairs Boston Healthcare System  West Roxbury Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pathology The Affiliated Changzhou N0.2 People's Hospital of Nanjing Medical University  Changzhou Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Lew","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Veterans Affairs Boston Healthcare System Harvard Medical School\/Brigham and Women's Hospital  West Roxbury Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pathology Nanjing Drum Tower Hospital of Nanjing University Medical School  Nanjing Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Wiener","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Veterans Affairs Boston Healthcare System Harvard Medical School\/Brigham and Women's Hospital  West Roxbury Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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