{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T01:27:06Z","timestamp":1782523626770,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":112,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Autoimmune hepatitis (AIH) is an aberrant autoimmune condition mediated by T cell abnormality, which may cause fulminant liver failure and persistent liver injury. This study aimed to disclose the histopathological and functional engagement of interleukin (IL)\u201026, a potent inflammation mediator, in AIH disease progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted immunohistochemical staining on liver biopsy samples to evaluate intrahepatic expression of IL\u201026. Cellular sources of hepatic IL\u201026 were detected by confocal microscopy. Flow cytometry was employed to determine the immunological alterations of CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T cells following <jats:italic>in vitro<\/jats:italic> IL\u201026 treatment on primary peripheral blood mononuclear cells from healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Statistically significant increase in IL\u201026 level was observed in AIH (n\u2009=\u200948) liver samples in comparison with patients having chronic hepatitis B (n\u2009=\u200925), nonalcoholic fatty liver disease (n\u2009=\u200918), and healthy donors for living donor liver transplantation\u00a0(n\u2009=\u200910). The number of intrahepatic IL\u201026<jats:sup>+<\/jats:sup> cells was positively correlated with histological and serological severity. An immunofluorescence staining indicated that liver\u2010infiltrating CD4<jats:sup>+<\/jats:sup> T cells, CD8<jats:sup>+<\/jats:sup> T cells, and CD68<jats:sup>+<\/jats:sup> macrophages orchestrated IL\u201026 secretion in AIH. Both CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T cells demonstrated effective activation, lytic, and proinflammatory functions upon IL\u201026 stimulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed elevated IL\u201026 in AIH liver which promoted T cell activation and cytotoxic capacity, indicating a therapeutic potential of IL\u201026 intervention in AIH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13174","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T15:29:31Z","timestamp":1683559771000},"page":"231-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>IL<\/scp>\u201026 modulates T cell function in autoimmune hepatitis"],"prefix":"10.1111","volume":"24","author":[{"given":"Wei","family":"He","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, National Health Council Key Laboratory of Digestive Diseases, State Key Laboratory for Oncogenes and Related Genes, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi Wei","family":"Qian","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, National Health Council Key Laboratory of Digestive Diseases, State Key Laboratory for Oncogenes and Related Genes, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology 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