{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:44:40Z","timestamp":1765547080943,"version":"3.40.5"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":97,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>In this case\u2013control study we aimed to investigate the intestinal microbiota profile of patients with Peutz\u2010Jeghers syndrome (PJS) and its association with polyp growth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two PJS patients and 35 healthy controls were enrolled. Fecal samples of all participants were collected for gut microbiota analysis via 16S rRNA gene (regions V3\u2013V4) sequencing. SPSS version 22.0 and R software version 3.1.0 were used for the statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The richness was comparable, while the overall structure of the gut microbiota differed significantly between the PJS and control groups (weighted UniFrac, <jats:italic>P<\/jats:italic>\u2009=\u20090.001; unweighted UniFrac, <jats:italic>P<\/jats:italic>\u2009=\u20090.008). Significantly different abundances of two phyla, seven families, and 18 genera as well as twenty\u2010nine differentially enriched functional modules (false discovery rate, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) between the two groups were identified. <jats:italic>Morganella<\/jats:italic> was positively associated with the median number of polyps (JPN; <jats:italic>r<\/jats:italic> =\u20090.96, <jats:italic>P<\/jats:italic> &lt;\u20090.001) and number of newly discovered polyps in the jejunum between two recent endoscopic resections (JPNG; <jats:italic>r<\/jats:italic>\u2009=\u20090.78, <jats:italic>P<\/jats:italic>\u2009=\u20090.04). <jats:italic>Desulfovibrio<\/jats:italic> was positively associated with JPNG (<jats:italic>r<\/jats:italic>\u2009=\u20090.87, <jats:italic>P<\/jats:italic>\u2009=\u20090.01). <jats:italic>Blautia<\/jats:italic> was negatively associated with the median maximum size of polyps in the jejunum (JPS). <jats:italic>Anaerostipes<\/jats:italic> was negatively associated with JPN, JPNG and JPS. <jats:italic>Clostridium XVIII<\/jats:italic> and <jats:italic>Fusicatenibacter<\/jats:italic> were negatively associated with JPN and JPS, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found remarkably different gut microbiota of patients with PJS compared to healthy individuals and associations between specific fecal bacteria and clinical features of PJS. These findings may provide a new perspective for the management of PJS in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13175","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T18:58:29Z","timestamp":1683745109000},"page":"203-212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Alterations and clinical relevance of gut microbiota in patients with <scp>Peutz\u2013Jeghers<\/scp> syndrome: A prospective study"],"prefix":"10.1111","volume":"24","author":[{"given":"Yu Xin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Tenth People's Hospital of Tongji University  Shanghai China"},{"name":"Department of Gastroenterology Changhai Hospital, Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua Bing","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Changhai Hospital, Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan Hang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Changhai Hospital, Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao Shen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Changhai Hospital, Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tenth People's Hospital of Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4261-6888","authenticated-orcid":false,"given":"Yi Qi","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Changhai Hospital, Naval Medical University  Shanghai 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