{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:39:09Z","timestamp":1773283149995,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":88,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170560"],"award-info":[{"award-number":["82170560"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the relationship between gastric cancer and its precancerous lesions and gastric xanthoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of 47\u2009736 patients who underwent gastroscopy in our center from January 2020 to December 2021 were reviewed. Patients\u2019 age, sex, endoscopic and histopathological findings, and the presence, number and location of gastric xanthoma were recorded. To investigate the detection rate of gastric xanthoma at different stages of gastric lesions, the participants were further divided into the chronic gastritis group (n\u2009=\u200942\u2009758), the precancerous lesion group (n\u2009=\u20093672), and the gastric cancer group (n\u2009=\u20091306), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall detection rate of gastric xanthoma was 2.85%, and it was most commonly observed in the gastric antrum (52.50%). In addition, gastric xanthoma was more common in men and more likely to be single lesion. It was most detected in the precancerous lesion group (8.39%), followed by the gastric cancer group (5.44%), and least in the chronic gastritis group (2.29%). Multivariate analysis showed that gastric xanthoma was closely related to precancerous lesions (odds ratio [OR] 3.197, 95% confidence interval [CI] 2.791\u20133.662, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and gastric cancer (OR 1.794, 95% CI 1.394\u20132.309, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Gastric xanthoma is closely related to gastric precancerous lesions and gastric cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13202","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T10:49:56Z","timestamp":1688726996000},"page":"340-347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Relationship between gastric xanthoma, gastric precancerous lesions, and gastric cancer: A retrospective study"],"prefix":"10.1111","volume":"24","author":[{"given":"Wei Na","family":"Shen","sequence":"first","affiliation":[{"name":"Xi'an Medical University  Xi'an Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Dong","family":"Qu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital Air Force Medical University  Xi'an Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha Sha","family":"Chen","sequence":"additional","affiliation":[{"name":"Xi'an Medical University  Xi'an Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Huan","family":"Liu","sequence":"additional","affiliation":[{"name":"Xi'an Medical University  Xi'an Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng Jie","family":"Gao","sequence":"additional","affiliation":[{"name":"Xi'an Medical University  Xi'an Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9515-7577","authenticated-orcid":false,"given":"Yong Quan","family":"Shi","sequence":"additional","affiliation":[{"name":"Xi'an Medical University  Xi'an Shaanxi Province China"},{"name":"State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital Air Force Medical University  Xi'an Shaanxi Province 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