{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:28:33Z","timestamp":1747182513327,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"6-7","license":[{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"vor","delay-in-days":74,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770598","82000533"],"award-info":[{"award-number":["81770598","82000533"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Primary biliary cholangitis (PBC) is a rare disease characterized by intrahepatic cholestasis, whereas gallstone disease (GD) is common. In this study, we aimed to investigate the prevalence and impact of GD on the prognosis of PBC in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of the PBC patients were retrospectively reviewed and their follow\u2010up data were obtained via regular structured, standardized telephone interviews. GD was defined as gallstones on ultrasonography or a history of cholecystectomy for gallstones. Propensity score matching (PSM) and Cox regression analysis were performed. The primary end\u2010point was liver\u2010related death and\/or liver transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 985 ursodeoxycholic acid (UDCA)\u2010treated PBC patients were enrolled with a median follow\u2010up duration of 5.3\u2009years (range 1.0\u201320.9\u2009years). Among them, 258 (26.2%) had GD, including 157 (22.9%) of non\u2010cirrhotic and 101 (33.8%) of cirrhotic patients. Compared with PBC without GD, those with GD were older, more often had type 2 diabetes mellitus, and had a more severe liver disease at baseline. After PSM (1:2), 229 PBC patients with GD were matched with 458 PBC patients without GD based on age, sex, cirrhosis, and total bilirubin level. The transplant\u2010free survival and incidence of hepatic events were similar between the two groups. Furthermore, multivariate Cox regression analysis showed that concomitant GD was not independently associated with a worse prognosis for PBC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Concomitant GD was common but was not associated with long\u2010term outcomes in patients with UDCA\u2010treated PBC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13207","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T05:04:46Z","timestamp":1689743086000},"page":"419-426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Concomitant gallstone disease was not associated with long\u2010term outcomes in ursodeoxycholic acid\u2010treated patients with primary biliary cholangitis"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8683-8677","authenticated-orcid":false,"given":"Sha","family":"Chen","sequence":"first","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital Capital Medical University; Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis; National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital Capital Medical University; Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis; National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bu Er","family":"Li","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital Capital Medical University; Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis; National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting Ting","family":"Lv","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital Capital Medical University; Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis; National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu Xiang","family":"Li","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital Capital Medical University; Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis; National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Shan","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital Capital Medical University; Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis; National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and EBM Unit, Beijing Friendship Hospital Capital Medical University; National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan Yuan","family":"Kong","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and EBM Unit, Beijing Friendship Hospital Capital Medical University; National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Experimental and Translational Research Center, Beijing Friendship Hospital Capital Medical University; Beijing Clinical Research Institute; Beijing Key Laboratory of Tolerance Induction and Organ Protection in Transplantation  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Ma","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital Capital Medical University; Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis; National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Juan","family":"Ou","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital Capital Medical University; Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis; National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9409-1158","authenticated-orcid":false,"given":"Hong","family":"You","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital Capital Medical University; Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis; National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1343-9667","authenticated-orcid":false,"given":"Wei Jia","family":"Duan","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital Capital Medical University; Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis; National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4673-8890","authenticated-orcid":false,"given":"Ji Dong","family":"Jia","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital Capital Medical University; Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis; National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,14]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1002\/hep.30145"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1111\/jgh.15329"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1007\/s12072-021-10276-6"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1155\/2017\/9749802"},{"issue":"1","key":"e_1_2_7_6_1","first-page":"9","article-title":"Gallstones and liver disease: an overview","volume":"20","author":"Conte D","year":"2011","journal-title":"J Gastrointestin Liver Dis."},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.1007\/s11894-005-0051-8"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.1016\/j.autrev.2017.07.002"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1002\/hep.510290618"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1016\/S0016-5085(76)80016-9"},{"doi-asserted-by":"publisher","key":"e_1_2_7_11_1","DOI":"10.1148\/radiographics.20.3.g00ma16751"},{"doi-asserted-by":"publisher","key":"e_1_2_7_12_1","DOI":"10.1002\/cre2.489"},{"doi-asserted-by":"publisher","key":"e_1_2_7_13_1","DOI":"10.1002\/hep.20907"},{"doi-asserted-by":"publisher","key":"e_1_2_7_14_1","DOI":"10.1111\/1751-2980.12687"},{"doi-asserted-by":"publisher","key":"e_1_2_7_15_1","DOI":"10.2337\/dc19-S002"},{"doi-asserted-by":"publisher","key":"e_1_2_7_16_1","DOI":"10.1097\/HJH.0000000000001940"},{"doi-asserted-by":"publisher","key":"e_1_2_7_17_1","DOI":"10.3350\/kjhep.2012.18.1.1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_18_1","DOI":"10.1016\/j.jhep.2011.12.001"},{"doi-asserted-by":"publisher","key":"e_1_2_7_19_1","DOI":"10.1002\/hep.22428"},{"doi-asserted-by":"publisher","key":"e_1_2_7_20_1","DOI":"10.1016\/j.jhep.2011.02.031"},{"issue":"6","key":"e_1_2_7_21_1","first-page":"1231","article-title":"Consensus on diagnosis and treatment of chronic cholecystitis and gall stones in China (2018)","volume":"35","author":"Editorial Board of Chinese Journal of Digestion, Cooperation Group of Hepatobiliary Disease of Chinese Society of Gastroenterology","year":"2019","journal-title":"J Clin Hepatol"},{"doi-asserted-by":"publisher","key":"e_1_2_7_22_1","DOI":"10.1136\/gutjnl-2016-313332"},{"doi-asserted-by":"publisher","key":"e_1_2_7_23_1","DOI":"10.1152\/ajpgi.00536.2001"},{"doi-asserted-by":"publisher","key":"e_1_2_7_24_1","DOI":"10.1038\/nrdp.2016.24"},{"doi-asserted-by":"publisher","key":"e_1_2_7_25_1","DOI":"10.1007\/s12072-017-9819-9"},{"doi-asserted-by":"publisher","key":"e_1_2_7_26_1","DOI":"10.3748\/wjg.v20.i23.7277"},{"doi-asserted-by":"publisher","key":"e_1_2_7_27_1","DOI":"10.3748\/wjg.v19.i31.5029"},{"doi-asserted-by":"publisher","key":"e_1_2_7_28_1","DOI":"10.1007\/s11695-017-2924-y"}],"container-title":["Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.13207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T02:08:56Z","timestamp":1694743736000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1751-2980.13207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":27,"journal-issue":{"issue":"6-7","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/1751-2980.13207"],"URL":"https:\/\/doi.org\/10.1111\/1751-2980.13207","archive":["Portico"],"relation":{},"ISSN":["1751-2972","1751-2980"],"issn-type":[{"type":"print","value":"1751-2972"},{"type":"electronic","value":"1751-2980"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"2022-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}