{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T22:37:08Z","timestamp":1768257428479,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"8-9","license":[{"start":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T00:00:00Z","timestamp":1694822400000},"content-version":"vor","delay-in-days":46,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Esophageal neuroendocrine carcinoma (ENEC) is a rare cancer that is highly malignant and related to a poor prognosis. In this retrospective study we aimed to elucidate the clinical characteristics, diagnosis and management of patients with ENEC and to evaluate the potential prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Altogether 82 patients diagnosed with ENEC between January 2009 and December 2020 at the Fudan University Shanghai Cancer Center were retrospectively enrolled. Patients\u2019 survival was analyzed using the Kaplan\u2013Meier and log\u2010rank methods. Univariate and multivariate analyses and a Cox regression model were used to identify the prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median overall survival (mOS) was 13\u2009months in all patients. Multivariate analysis revealed that advanced tumor stage (hazard ratio [HR] 2.67, 95% confidence interval [CI] 1.07\u20136.66, <jats:italic>P<\/jats:italic>\u2009=\u20090.0353), liver (HR 3.36, 95% CI 1.53\u20137.41, <jats:italic>P<\/jats:italic>\u2009=\u20090.0026) and lung metastasis (HR 3.37, 95% CI 1.20\u20139.51, <jats:italic>P<\/jats:italic>\u2009=\u20090.0214) were associated with a poor prognosis. While positive chromogranin A (CgA) expression was related to a favorable outcome (HR 0.21, 95% CI 0.09\u20130.49, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Also, patients had adjustment of chemotherapy (dose reduction or less than three cycles) were prone to a worse prognosis compared with those did not (HR 4.36, 95% CI 2.10\u20139.08, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with ENEC, advanced cancer stage, adjustment of chemotherapy, liver and lung metastasis were associated with a poor survival, while CgA expression was related to a favorable prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13219","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T21:53:21Z","timestamp":1692654801000},"page":"472-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinicopathological features, treatment modalities, and prognosis of esophageal neuroendocrine carcinoma: A single\u2010center retrospective study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1174-7049","authenticated-orcid":false,"given":"Yao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Thoracic Medical Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Thoracic Oncology, Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao Tao","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medical Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Thoracic Oncology, Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medical Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of 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Thoracic Oncology, Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medical Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Thoracic Oncology, Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medical Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Thoracic Oncology, Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Hua","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medical Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of 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