{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:18:42Z","timestamp":1781522322452,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":35,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This pilot study aimed to evaluate the efficacy and safety of domperidone for the treatment of Chinese patients with functional dyspepsia (FD) who were diagnosed according to the Rome IV criteria and to identify the FD subtypes that potentially responded better to domperidone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter prospective study was conducted in China from August 2018 to July 2020, consisting of a 1\u2010week screening phase and a 2\u2010week double\u2010blind treatment phase. Participants were randomized to receive domperidone 10\u2009mg or matching placebo tablets thrice daily for 14\u2009days. The primary end\u2010point was the overall treatment effect (OTE) response rate after 2\u2010week therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altogether 160 patients were included, with 80 patients in each group. The OTE response rate after 2\u2010week therapy was significantly higher for domperidone compared with placebo (60.7% vs 46.0%; relative risk [RR] 1.318, 95% confidence interval [CI] 0.972\u20131.787). Moreover, the OTE response rate after 2\u2010week domperidone or placebo treatment was 60.3% versus 54.9% for postprandial distress syndrome (PDS) (RR 1.098, 95% CI 0.750\u20131.607) and 60.6% versus 35.2% for overlapping PDS\u2013epigastric pain syndrome (EPS) (RR 1.722, 95% CI 0.995\u20132.980). Adverse events were reported by seven patients in the domperidone group and 12 patients in the placebo group. None of the adverse events in the domperidone group were serious.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Domperidone showed a positive pattern regarding OTE response rates after 2\u2010week therapy compared to placebo in patients with FD, as well as in subtypes of PDS and overlapping PDS\u2013EPS. No new safety issue was observed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13237","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T09:11:20Z","timestamp":1698657080000},"page":"603-610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Treatment of functional dyspepsia in Chinese adult patients with domperidone: A multicenter, randomized, double\u2010blind, placebo\u2010controlled pilot study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5600-8779","authenticated-orcid":false,"given":"Xiu Cai","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2165-9280","authenticated-orcid":false,"given":"Zhi Hui","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Fujian Provincial Hospital Shengli Clinical Medical College of Fujian Medical University  Fuzhou Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Dong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De An","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Sheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Fujian Provincial Hospital Shengli Clinical Medical College of Fujian Medical University  Fuzhou Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan Dong","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui Jun","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Min","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Janssen China R&amp;D  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"OTC Medical Affairs, Xi'an Janssen Pharmaceutical Ltd  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng Yu","family":"Li","sequence":"additional","affiliation":[{"name":"OTC Medical Affairs, Xi'an Janssen Pharmaceutical Ltd  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Xu","sequence":"additional","affiliation":[{"name":"OTC Medical Affairs, Xi'an Janssen Pharmaceutical Ltd  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318536"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2016.091"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01362-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.014"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.011"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01706.x"},{"issue":"10","key":"e_1_2_6_8_1","article-title":"Prokinetics for functional dyspepsia","volume":"10","author":"Pittayanon R","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01255.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(00)02314-5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010017\u20100639\u20100"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00913"},{"issue":"12","key":"e_1_2_6_13_1","first-page":"832","article-title":"The guideline for management of dyspepsia in China (2007, Dalian)","volume":"27","author":"Study Group of Gastrointestinal Motility, Chinese Society of Gastroenterology, Chinese Medical Association","year":"2007","journal-title":"Chin J Dig"},{"issue":"4","key":"e_1_2_6_14_1","first-page":"217","article-title":"Chinese consensus on the management of functional dyspepsia (2015, Shanghai)","volume":"36","author":"Study Group of Gastrointestinal Motility, Study Group of Functional Gastrointestinal Disorders, Chinese Society of Gastroenterology, Chinese Medical Association","year":"2016","journal-title":"Chin J Dig."},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm20190"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301454"},{"key":"e_1_2_6_17_1","first-page":"106","article-title":"Validation of seven graded diary cards for severity of dyspeptic symptoms in patients with non ulcer dyspepsia","volume":"583","author":"Junghard O","year":"1998","journal-title":"Eur J Surg Suppl"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01363.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/030006057900700208"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i5.613"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.132449"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000033"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12805"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2019.1543586"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13544"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rgmx.2018.03.007"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2017.066"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01535938"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm20250"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000485409"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640618799153"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4272-5"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/AC.66.4.2126588"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.16.1883"}],"container-title":["Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.13237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:15:02Z","timestamp":1704154502000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1751-2980.13237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/1751-2980.13237"],"URL":"https:\/\/doi.org\/10.1111\/1751-2980.13237","archive":["Portico"],"relation":{},"ISSN":["1751-2972","1751-2980"],"issn-type":[{"value":"1751-2972","type":"print"},{"value":"1751-2980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"2022-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}