{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T16:00:26Z","timestamp":1793289626582,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["21Y11908200"],"award-info":[{"award-number":["21Y11908200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate the performance of the FibroTouch\u2010based ultrasound attenuation parameter (UAP) for assessing hepatic steatosis in nonalcoholic fatty liver disease (NAFLD), with magnetic resonance imaging proton density fat fraction (MRI\u2010PDFF) as the reference standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, cross\u2010sectional study included 275 individuals in the training group and 110 individuals in the validation group, all of whom completed a standardized research visit, laboratory tests, MRI\u2010PDFF, and UAP measurements over 1\u2009month. Pearson correlation coefficient and Bland\u2013Altman analysis were used to assess the agreement between UAP and MRI\u2010PDFF for the detection of hepatic steatosis. The diagnostic value of UAP was evaluated by the area under the receiver operating characteristic (ROC) curve (AUROC). Confounding factors to UAP performance were identified by ROC curves and regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The AUROC of UAP for detecting MRI\u2010PDFF at \u22655%, \u226510%, and \u226520% were 0.95 (95% confidence interval [CI] 0.92\u20130.97), 0.86 (95% CI 0.81\u20130.90), and 0.90 (95% CI 0.86\u20130.93), respectively, and their optimal thresholds were 259, 274, and 295\u2009dB\/m, respectively. The UAP measurements had higher diagnostic accuracy in participants with lower waist circumference (\u226490\u2009cm for men and \u226480\u2009cm for women) compared to those with higher waist circumference (AUROC values: 0.97 vs 0.84, <jats:italic>P<\/jats:italic> &lt; 0.05). Bland\u2013Altman analysis showed good agreement between UAP and MRI\u2010PDFF (bias 0.00021). According to established regression analyses, hepatic steatosis could be accurately diagnosed using UAP estimation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FibroTouch\u2010UAP has a high diagnostic potential for hepatic steatosis in NAFLD patients and helps clinical assessment and monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13242","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T18:43:40Z","timestamp":1700765020000},"page":"691-701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic value of <scp>FibroTouch<\/scp> in identifying hepatic steatosis in <scp>NAFLD<\/scp> with <scp>MRI\u2010PDFF<\/scp> as the reference standard"],"prefix":"10.1111","volume":"24","author":[{"given":"Rong","family":"Mu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Shanghai General Hospital, Shanghai Jiao Tong 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