{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T20:24:48Z","timestamp":1749414288700,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T00:00:00Z","timestamp":1705190400000},"content-version":"vor","delay-in-days":44,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the clinicopathological and prognostic significance of intestinal metaplasia (IM) in endoscopically resected early gastric carcinoma (EGC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Altogether 136 consecutive cases with EGC resected by endoscopic submucosal dissection over 5\u2009years were included and divided into the\u00a0early gastric cardiac (EGCC; n\u2009=\u200960) and non\u2010cardiac carcinoma (EGNCC; n\u2009=\u200976) groups. Goblet cell IM and subtypes were determined with histology and immunostaining. Recurrence\u2010free survival (RFS) was compared among various IM groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IM was identified in 128 (94.1%) EGC cases, including complete IM (n\u2009=\u200939), incomplete IM (n\u2009=\u200927), and mixed IM (n\u2009=\u200962). Incomplete IM was significantly more common in EGCC and exhibited a lower frequency of en bloc resection than the complete subtype. The frequency of synchronous or metachronous gastric tumor was significantly more common in EGCC with complete IM than in those with incomplete IM. Compared to EGC without IM, EGC with IM showed a significantly higher frequency of non\u2010poorly cohesive carcinoma, en bloc resection, and non\u2010eCuraC\u20101 grade. EGNCC with IM was significantly associated with negative resection margins and en bloc resection. The 5\u2010year RFS was significantly lower in EGNCC patients with incomplete IM compared with those with mixed IM. The independent risk factors for RFS included tumor size &gt;2\u2009cm and eCuraC\u20101 grade.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Subtyping IM in EGC helped predict endoscopic resectability, prognosis, and risk of synchronous or metachronous gastric tumor. The significance of IM differed between EGCC and EGNCC. Large studies with longer follow\u2010up are warranted to validate our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13245","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T18:52:58Z","timestamp":1702666378000},"page":"660-670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinicopathological significance of intestinal metaplasia in endoscopically resected early gastric carcinoma"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1806-9893","authenticated-orcid":false,"given":"Yu Qing","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Pathology Affiliated Changzhou Second People's Hospital of Nanjing Medical University  Changzhou Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Affiliated Changzhou Second People's Hospital of Nanjing Medical University  Changzhou Jiangsu Province China"},{"name":"Graduate School of Dalian Medical University  Dalian Liaoning Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao Hua","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Changzhou Second People's Hospital of Nanjing Medical University  Changzhou Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology Affiliated Changzhou Second People's Hospital of Nanjing Medical University  Changzhou Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology Affiliated Changzhou Second People's Hospital of Nanjing Medical University  Changzhou Jiangsu Province China"},{"name":"Department of Pathology Beth Israel Deaconess Medical Center and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,14]]},"reference":[{"volume-title":"Global Cancer Observatory: Cancer Today","year":"2020","author":"Ferlay J","key":"e_1_2_7_2_1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2011.00550.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1979.tb02996.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31571"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935\u2010021\u201001869\u20100"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.12.004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000237"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001665"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5063-y"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0063-1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep13439"},{"key":"e_1_2_7_13_1","first-page":"85","volume-title":"WHO Classification of Tumours Editorial Board. 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