{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:05:54Z","timestamp":1793973954362,"version":"4.8.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T00:00:00Z","timestamp":1707609600000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the clinical potential and safety of Moluodan to reverse gastric precancerous lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients aged 18\u201370\u2009years diagnosed with moderate\u2010to\u2010severe atrophy and\/or moderate\u2010to\u2010severe intestinal metaplasia, with or without low\u2010grade dysplasia, and negative for\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      were recruited in this randomized, double\u2010blind, parallel\u2010controlled trial. The primary outcome was the improvement of global histological diagnosis at 1\u2010year follow\u2010up endoscopy using the operative link for gastritis assessment, the operative link for gastric intestinal metaplasia assessment, and the disappearance rate of dysplasia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between November 3, 2017 and January 27, 2021, 166 subjects were randomly assigned to the Moluodan group, 168 to the folic acid group, 84 to the combination group, and 84 to the high\u2010dose Moluodan group. The improvement in global histological diagnosis was achieved in 60 (39.5%) subjects receiving Moluodan, 59 (37.8%) receiving folic acid, 26 (32.1%) receiving the combined drugs, and 36 (47.4%) receiving high\u2010dose Moluodan. Moluodan was non\u2010inferior to folic acid (95% confidence interval: \u22129.2 to 12.5;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02). High\u2010dose Moluodan had a trend for better protective efficacy, though there was no statistical significance. The disappearance rate of dysplasia was 82.8% in the Moluodan group, which was superior to folic acid (53.9%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.006). No drug\u2010related serious adverse events were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>One pack of Moluodan three times daily for 1 year was safe and effective in reversing gastric precancerous lesions, especially dysplasia. Doubling its dose showed a better efficacy trend.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1751-2980.13251","type":"journal-article","created":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T21:48:45Z","timestamp":1707688125000},"page":"27-35","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effectiveness and safety of\n                    <scp>Moluodan<\/scp>\n                    in the treatment of precancerous lesions of gastric cancer: A randomized clinical trial"],"prefix":"10.1111","volume":"25","author":[{"given":"Tian Hui","family":"Zou","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Shanghai Institute of Digestive Disease, State Key Laboratory of Systems Medicine for Cancer, NHC Key Laboratory of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9422-300X","authenticated-orcid":false,"given":"Qin Yan","family":"Gao","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Shanghai Institute of Digestive Disease, State Key Laboratory of Systems Medicine for Cancer, NHC Key Laboratory of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si De","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nanfang Hospital, Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0575-0399","authenticated-orcid":false,"given":"Yan Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang Jun","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Gut Microecology and Associated Major Diseases Research; Center for Digestive Diseases Research and Clinical Translation of Shanghai Jiaotong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Jiangsu Province Hospital  Nanjing Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi Bin","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Affiliated Hospital of Qingdao University  Qingdao Shandong Province 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Hepatology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9578-2580","authenticated-orcid":false,"given":"Jing Nan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Peking Union Medical College Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong Yin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Renmin Hospital of Wuhan University  Wuhan Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Shengjing Hospital of China Medical University  Shenyang Liaoning Province 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