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This study aimed to evaluate the differences in perceptions of PBC among physicians from different hospital departments and patients with PBC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An online survey regarding the general knowledge, diagnosis, and management of PBC was completed by physicians and patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 239 patients with PBC and 239 physicians from eight hospital departments (gastroenterology, infectious diseases, rheumatology, hepatobiliary surgery, pathology, clinical laboratory, ultrasound, and radiology) completed the survey. The results showed that physicians from departments other than gastroenterologists and rheumatologists lacked knowledge of PBC, and that junior gastroenterologists were uncertain about the diagnostic and treatment pathways of PBC. Importantly, the lack of knowledge significantly impacted the QoL of patients, especially the emotional scores of PBC\u201040 (odds ratio \u22122.556, 95% confidence interval \u22123.852 to \u22121.260, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In addition, there was a perceived knowledge gap between patients and gastroenterologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Physicians must improve their awareness of PBC. Patient education and patient\u2013physician communication are important for improving the patient's QoL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13254","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T02:10:59Z","timestamp":1708999859000},"page":"61-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Differences in the perceptions of patients with primary biliary cholangitis and physicians from various hospital departments: An online survey"],"prefix":"10.1111","volume":"25","author":[{"given":"Yan Sheng","family":"Liu","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Xijing Hospital Air Force Military Medical University  Xi'an Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui","family":"Jia","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Xijing Hospital Air Force Military Medical University  Xi'an Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da Wei","family":"Ding","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Xijing Hospital Air Force Military Medical University  Xi'an Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin Hua","family":"Zheng","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Xijing Hospital Air Force Military Medical University  Xi'an Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui Qing","family":"Sun","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Xijing Hospital Air Force Military Medical University  Xi'an Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Xijing Hospital Air Force Military Medical University  Xi'an Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Deng","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Xijing Hospital Air Force Military Medical University  Xi'an Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Mei","family":"Yang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Xijing Hospital Air Force Military Medical University  Xi'an Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Na","family":"Cui","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Xijing Hospital Air Force Military Medical University  Xi'an Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Cun","family":"Guo","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Xijing Hospital Air Force Military Medical University  Xi'an Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Long","family":"Shang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Xijing Hospital Air Force Military Medical University  Xi'an Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3046-9507","authenticated-orcid":false,"given":"Ying","family":"Han","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Xijing Hospital Air Force Military Medical University  Xi'an Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"issue":"6","key":"e_1_2_7_2_1","first-page":"860","article-title":"Symptoms burden and health\u2010related quality of life in Chinese 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