{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:17:40Z","timestamp":1791494260339,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T00:00:00Z","timestamp":1711843200000},"content-version":"vor","delay-in-days":59,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association between disease location and segmental mucosal healing (SMH) following exclusive enteral nutrition (EEN) in children with Crohn's disease (CD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Treatment\u2010naive pediatric patients with endoscopically active CD treated with EEN alone as induction therapy were retrospectively enrolled from January 1, 2017 to June 30, 2022. The\u00a0simple\u00a0endoscopic score for CD (SES\u2010CD) was employed to score disease activity in the\u00a0upper gastrointestinal (GI) tract (esophagus, stomach, duodenum), rectum, left colon, transverse colon, right colon, and terminal ileum. While the Lewis score assessed that of the small bowel from the jejunum to the proximal ileum (except the terminal ileum). The variation in the total scores for each segment and SES\u2010CD subscores for each ileocolonic segment from baseline to 1\u2009year after EEN therapy and the segmental endoscopic outcomes and potential predictors associated with SMH for the segments scored by SES\u2010CD were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 82 children with CD were enrolled. Except for the upper GI segment, scores in other segments declined significantly from baseline to EEN completion (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). We analyzed 486 segments (79, 80, 81, 82, 82 and 82 from upper GI\u2009tract, terminal ileum, right colon, transverse colon, left colon, and rectum) and found that the segmental SES\u2010CD at baseline (odds ratio [OR]\u20090.62, 95% confidence interval [CI]\u20090.55\u20130.70, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and upper GI location (OR\u20090.25, 95% CI\u20090.11\u20130.55, <jats:italic>P\u2009=<\/jats:italic>\u20090.001) were associated with SMH at EEN completion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Disease location of the upper GI segment in pediatric CD was associated with SMH following EEN therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13260","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T01:51:01Z","timestamp":1711936261000},"page":"123-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of exclusive enteral nutrition on the mucosal healing of different gastrointestinal segments in children with <scp>Crohn's<\/scp> disease"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8513-905X","authenticated-orcid":false,"given":"Wen Juan","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0626-4555","authenticated-orcid":false,"given":"Peng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7157-0738","authenticated-orcid":false,"given":"Hai Jiao","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6831-3981","authenticated-orcid":false,"given":"Jie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4433-5473","authenticated-orcid":false,"given":"Yu Huan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1233-7220","authenticated-orcid":false,"given":"Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center Children's Hospital of Fudan University, National Children's Medical Center  Shanghai 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