{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:41:31Z","timestamp":1789800091251,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Synchronous adenomas of the major and minor duodenal papilla are seldom reported. The aim of this study was to describe the characteristics of synchronous major and minor papilla adenomas and to evaluate the safety and efficacy of endoscopic papillectomy (EP) for the management of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients who underwent endoscopy for synchronous major and minor papilla adenomas from January 1, 2013 to August 31, 2023 were analyzed retrospectively. Patients\u2019 characteristics, clinical manifestations, laboratory, imaging and endoscopic findings were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The nine patients with synchronous major and minor papilla adenomas had an average age of 50.78\u2009\u00b1\u200910.70\u2009years. The diameter of major and minor papilla adenomas was 12.11\u2009\u00b1\u20093.41\u2009mm and 6.11\u2009\u00b1\u20091.05\u2009mm, respectively. Most major papilla adenomas had R0 horizontal margins (n\u2009=\u20098), while R0 vertical margins were achieved in all patients. While minor papilla adenomas were resected with both R0 horizontal and vertical margins in all patients. Post\u2010EP bleeding was observed in one patient, which was classified as mild. Post\u2010EP hyperamylasemia and pancreatitis was observed in two and four patients, respectively; the latter consisted of three with mild pancreatitis and one with severe pancreatitis. No perforation was observed. The mean follow\u2010up duration was 9.22\u2009\u00b1\u20095.99\u2009months. Histologically confirmed recurrence at the resection site was detected in one patient at 3 months after the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Synchronous major and minor papilla adenomas may not be as rare as previously speculated. EP may be an effective and safe alternative modality for their\u00a0management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13269","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T05:59:04Z","timestamp":1714197544000},"page":"222-229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Endoscopic papillectomy for synchronous adenoma of the major and minor duodenal papilla"],"prefix":"10.1111","volume":"25","author":[{"given":"Jin Pei","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui 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