{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T17:06:12Z","timestamp":1761239172980,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":58,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are prevalent functional gastrointestinal disorders (FGIDs). In this study we aimed to explore the causal association between physical activity or sedentary behavior and the risk of FD and IBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Mendelian randomization (MR) analysis was employed. Candidate genetic instruments for physical activity and sedentary behavior were retrieved from the latest published Genome\u2010Wide Association Study (GWAS), which included up to 703 901 participants. Summary\u2010level GWAS data for FD (8 875 cases and 320 387 controls) and IBS (9 323 cases and 301 931 controls) were obtained from the FinnGen study. The causal effects were mainly estimated by inverse variance weighted (IVW) method. Sensitivity analyses were implemented with Cochran's <jats:italic>Q<\/jats:italic> test, MR\u2010Egger intercept test, leave\u2010one\u2010out analysis, and the funnel plot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant association of moderate\u2010to\u2010vigorous intensity physical activity (MVPA), leisure screen time (LST), sedentary behavior at work (SDW), and sedentary commuting (SDC) with the risk of FD was found. However,\u00a0there was a suggestive correlation between MVPA and the decreased risk of FD (odds ratio [OR]\u20090.63, 95% confidence interval [CI]\u20090.39\u20130.99, <jats:italic>P<\/jats:italic>\u2009=\u20090.047). Genetically predicted MVPA decreased the risk of IBS (OR\u20090.58, 95% CI\u20090.40\u20130.84, <jats:italic>P<\/jats:italic>\u2009=\u20090.004), while increased LST was positively associated with IBS risk (OR\u20091.33, 95% CI\u20091.15\u20131.53, <jats:italic>P<\/jats:italic> &lt;\u20090.001). No causal effects of SDW or SDC on IBS risk were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MVPA and LST are causally linked to the development of IBS, which will facilitate primary prevention of IBS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13274","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T10:10:11Z","timestamp":1716977411000},"page":"248-254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Physical activity, sedentary behavior, and the risk of functional gastrointestinal disorders: A two\u2010sample Mendelian randomization study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7545-437X","authenticated-orcid":false,"given":"Yan Rui","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Renmin Hospital of Wuhan University  Wuhan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zong Biao","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Renmin Hospital of Wuhan University  Wuhan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Renmin Hospital of Wuhan University  Wuhan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Renmin Hospital of Wuhan University  Wuhan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei Guo","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Renmin Hospital of Wuhan University  Wuhan Hubei Province 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