{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:08:12Z","timestamp":1793362092522,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to evaluate the clinical response to cholestyramine in patients with functional chronic diarrhea and a high clinical suspicion of bile\u2010acid diarrhea (BAD) investigated with 75\u2010selenium homocholic acid taurine (SeHCAT) test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult patients attending our outpatient clinic between January and December 2021 for chronic diarrhea with suspicion of BAD were proposed SeHCAT testing and a therapeutic trial of cholestyramine 4\u20138\u2009g daily. Clinical response to cholestyramine was evaluated at 1, 3, 6, and 12\u2009months. Clinical and demographic data were analyzed according to SeHCAT test results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 50 patients with chronic diarrhea and clinical suspicion of BAD, 13 (26.0%) refused either SeHCAT testing or cholestyramine therapy. Finally, 37 patients (31 females, age 44\u2009\u00b1\u200914\u2009years) agreed to undergo SeHCAT and were started on cholestyramine (median follow\u2010up 14\u2009months [interquartile range 6\u201316 months]). Initial response to cholestyramine was similar in patients with positive and negative SeHCAT test results, but improved over time in those with a positive test result. Long\u2010term response (100% vs 65.2%, <jats:italic>P<\/jats:italic>\u2009=\u20090.02) and necessity of maintenance therapy for symptom control were more common in those with positive SeHCAT test result (71.4% vs 26.1%, <jats:italic>P<\/jats:italic>\u2009=\u20090.02). However, response to cholestyramine was also frequent in patients with a negative test result.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The SeHCAT test accurately identifies patients with BAD who benefit from long\u2010term cholestyramine treatment. Nevertheless, cholestyramine may be also effective in patients with chronic diarrhea but negative SeHCAT test result.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13289","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T06:33:51Z","timestamp":1718951631000},"page":"279-284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison between SeHCAT test and clinical response to cholestyramine in patients with chronic diarrhea and high suspicion of bile acid malabsorption: A single\u2010center prospective study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8493-7698","authenticated-orcid":false,"given":"Annalisa","family":"Schiepatti","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Medical Therapy University of Pavia  Pavia Italy"},{"name":"Gastroenterology Unit of Pavia Institute Istituti Clinici Scientifici Maugeri IRCCS  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Bossert","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit Istituti Clinici Scientifici Maugeri SpA SB IRCCS  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Cincotta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Therapy University of Pavia  Pavia Italy"},{"name":"Gastroenterology Unit of Pavia Institute Istituti Clinici Scientifici Maugeri IRCCS  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Arianna","family":"Zanini","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2057-8179","authenticated-orcid":false,"given":"Stiliano","family":"Maimaris","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Therapy University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"D'Ambrosio","sequence":"additional","affiliation":[{"name":"Medical Physics Unit Istituti Clinici Scientifici Maugeri SpA SB IRCCS  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Trifir\u00f2","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit Istituti Clinici Scientifici Maugeri SpA SB IRCCS  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2227-4622","authenticated-orcid":false,"given":"Federico","family":"Biagi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Therapy University of Pavia  Pavia Italy"},{"name":"Gastroenterology Unit of Pavia Institute Istituti Clinici Scientifici Maugeri IRCCS  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315909"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12684"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2017-100808"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000696"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.11.006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.04.024"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199808)15:8<651::AID-DIA628>3.0.CO;2-A"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100465"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13227"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.03.002"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2097359"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2017-100826"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.15-3-252"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12969"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13320"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04081.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305965"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00194.2001"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106644"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.07.052"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.06.024"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-324598"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001036"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jcag\/gwy071"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2022.11.015"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2023.2293814"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17739"}],"container-title":["Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.13289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T05:05:35Z","timestamp":1720415135000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1751-2980.13289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/1751-2980.13289"],"URL":"https:\/\/doi.org\/10.1111\/1751-2980.13289","archive":["Portico"],"relation":{},"ISSN":["1751-2972","1751-2980"],"issn-type":[{"value":"1751-2972","type":"print"},{"value":"1751-2980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"2024-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}