{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:15:27Z","timestamp":1793445327274,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":51,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Familial Crohn's disease (CD) accounts for approximately 1.5%\u201322.5% of all CD cases worldwide. We aimed to assess the concordance in disease subtype and phenotypic features among patients with CD and their relatives based on data from a large, well\u2010characterized, referral center\u2010based cohort in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was conducted on patients with familial CD who were admitted to the Sixth Affiliated Hospital of Sun Yat\u2010sen University between January 2012 and June 2022. We analyzed the disease characteristics and performed a concordance analysis within the same family among patients with familial CD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 5150 patients, 70 (1.4%) had a family history of Crohn's disease. The median age of the patients at initial diagnosis did not differ significantly between the probands and successors of family members with CD (<jats:italic>p<\/jats:italic>\u2009=\u20090.25). At the initial diagnosis, 54 first\u2010degree relatives showed moderate concordance in age (\u03ba\u2009=\u20090.50) and disease location (\u03ba\u2009=\u20090.44). At the last follow\u2010up visit, all family members and first\u2010degree relatives showed good concordance in upper gastrointestinal involvement (\u03ba\u2009=\u20090.67 and\u20090.62) and stricturing or penetrating behavior (\u03ba\u2009=\u20090.69 and \u20090.77), respectively. Patients with familial CD within the same family showed moderate agreement regarding anti\u2010tumor necrosis factor \u03b1 monoclonal antibody use and treatment efficacy (\u03ba\u2009=\u20090.44 and 0.42) and mild agreement regarding the efficacy and adverse reactions of thiopurine (\u03ba\u2009=\u20090.26 and 0.35).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The proportion of patients with familial CD in China may be relatively low. The consistency of certain disease features in familial CD may be associated with the degree of kinship and convergence with longer follow\u2010up duration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13304","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:57:23Z","timestamp":1724288243000},"page":"444-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Concordance of phenotypic characteristics among patients with familial <scp>Crohn's<\/scp> disease in <scp>China<\/scp>"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3873-6242","authenticated-orcid":false,"given":"Xiao Xia","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7517-638X","authenticated-orcid":false,"given":"Min Zhi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3058-4655","authenticated-orcid":false,"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3650-4931","authenticated-orcid":false,"given":"Xin Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1494-0282","authenticated-orcid":false,"given":"Yan Hui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2342-0422","authenticated-orcid":false,"given":"Kang","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7611-7390","authenticated-orcid":false,"given":"Jian","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.01.063"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab112"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3760"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.24"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8050404"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx154"},{"issue":"1","key":"e_1_2_7_8_1","first-page":"14","article-title":"Familial and ethnic risk in inflammatory bowel disease","volume":"31","author":"Santos MPC","year":"2018","journal-title":"Ann Gastroenterol"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2008.11.002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)91618-1"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.08.010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjw063"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v7.i4.556"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384\u2010024\u201004688\u20107"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2009.02094.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.029"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.082909"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16091272"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S210512"},{"issue":"1","key":"e_1_2_7_20_1","first-page":"S30","article-title":"Clinical use and practical application of TPMT enzyme and 6\u2010mercaptopurine metabolite monitoring in IBD","volume":"3","author":"Seidman EG","year":"2003","journal-title":"Rev Gastroenterol Disord"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0026256"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.05.047"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i1.118"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4175923"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12164"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2010.00421.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2016.14.2.111"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655200451207"}],"container-title":["Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.13304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T15:43:43Z","timestamp":1727279023000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1751-2980.13304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/1751-2980.13304"],"URL":"https:\/\/doi.org\/10.1111\/1751-2980.13304","archive":["Portico"],"relation":{},"ISSN":["1751-2972","1751-2980"],"issn-type":[{"value":"1751-2972","type":"print"},{"value":"1751-2980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-01-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}