{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T04:12:12Z","timestamp":1745986332467,"version":"3.40.4"},"reference-count":24,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":61,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Double\u2010balloon enteroscopy (DBE) is effective for managing small bowel (SB) diseases. We aimed to evaluate the patient outcomes of DBE polypectomy in Peutz\u2013Jeghers syndrome (PJS) with large SB polyps at surveillance imaging studies and to identify the risk factors for SB surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010five PJS patients who underwent regular SB surveillance imaging studies from 2005 to 2023 were retrospectively included. DBE was performed for polyps &gt;\u200915\u2009mm detected by imaging studies, and DBE polypectomy was conducted for those &gt;\u200910\u2009mm or symptomatic ones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients' average age at PJS diagnosis and surveillance initiation was 19.9 and 27.8\u2009years, respectively. Thirty\u2010one (68.9%) patients had laparotomy before surveillance. Each patient underwent 2.7 DBE procedures at a 31.0\u2010month interval. An average of 7.8 and 4.4 polyps were removed during the first and second DBE procedures (<jats:italic>p<\/jats:italic>\u2009=\u20090.070). During 9 (8.2%) DBE procedures, complications, including two perforations requiring surgery, occurred. During the follow\u2010up period, 11 patients required SB surgery, with a median time to surgery of 155\u2009months. Patients with \u2265\u20095 polyps removed at initial DBE had a higher cumulative probability of SB surgery than those with &lt;\u20095 polyps (hazard ratio [HR] 9.65, <jats:italic>p<\/jats:italic>\u2009=\u20090.031). Patients with \u2265\u20093 laparotomies before surveillance tended to have an increased surgery risk (HR 9.98, <jats:italic>p<\/jats:italic>\u2009=\u20090.078).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DBE polypectomy effectively manages large SB polyps detected by imaging surveillance in PJS over the long term. Early initiation of surveillance should be emphasized to minimize the risk of SB surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13335","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T21:11:18Z","timestamp":1741727478000},"page":"44-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Outcomes of Double\u2010Balloon Enteroscopy Polypectomy for Large Small Bowel Polyps Detected During Surveillance Imaging in Patients With Peutz\u2013Jeghers Syndrome"],"prefix":"10.1111","volume":"26","author":[{"given":"Min Kyu","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Wook","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Wook","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7756-2704","authenticated-orcid":false,"given":"Dong\u2010Hoon","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byong Duk","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Jae","family":"Myung","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk\u2010Kyun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9793-6379","authenticated-orcid":false,"given":"Jeong\u2010Sik","family":"Byeon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of 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