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Drugs commonly used in primary care, such as anti\u2010infective agents and nonsteroidal anti\u2010inflammatory drugs, are major causes of DILI. In addition, a large elderly population, comorbidities, and combination therapy with multiple drugs increase the risk of DILI in primary care. Therefore, primary care providers should proactively screen and monitor high\u2010risk patients to identify potential DILI timely. Currently, diagnosis of DILI relies on the exclusion of liver diseases of other etiologies. Collection of detailed medical history of the patients and careful exclusion of other potential liver injury of other etiologies are crucial for accurate diagnosis. This guideline, developed based on evidence\u2010based medicine from the latest research, aimed to provide primary care providers with professional guidance on the timely identification of suspected DILI cases and standardized diagnosis and management in clinical practice.<\/jats:p>","DOI":"10.1111\/1751-2980.13337","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T13:13:36Z","timestamp":1744118016000},"page":"2-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Chinese Guideline for the Diagnosis and Management of\u00a0Drug\u2010Induced Liver Injury in Primary Care (2024)"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2928-3425","authenticated-orcid":false,"given":"Yi Min","family":"Mao","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine Shanghai Jiao Tong University, 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