{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T06:54:27Z","timestamp":1758351267681,"version":"3.44.0"},"reference-count":31,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T00:00:00Z","timestamp":1750550400000},"content-version":"vor","delay-in-days":52,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7232081"],"award-info":[{"award-number":["7232081"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2304400"],"award-info":[{"award-number":["2022YFC2304400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the efficacy and safety profile of arginine glutamate and L\u2010ornithine\u2010L\u2010aspartate (LOLA) in treating mild hepatic encephalopathy (HE) and hyperammonemia in cirrhotic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010center, open\u2010label, non\u2010inferiority, randomized controlled trial (RCT) enrolled patients aged 18\u201375\u2009years with cirrhosis and mild HE. The patients were randomly allocated in the ratio of 1:1 using a randomization table to be treated with intravenous administration of arginine glutamate or LOLA for 7\u2009days. The primary end\u2010point was the clinical improvement of mild HE. Secondary end\u2010points included post\u2010treatment change in blood ammonia level and the time to complete the number connection test (NCT)\u2010A. Adverse events and adverse drug reactions were documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From July 2020 to June 2021, 108 cirrhotic patients with mild HE were included and randomized to receive either arginine glutamate or LOLA for 7\u2009days. Clinical improvement was observed in 88.9% of the patients receiving arginine glutamate and 90.7% of those having LOLA (between\u2010group difference \u22121.9%, 95% confidence interval\u00a0\u221213.3% to 9.6%), indicating non\u2010inferiority of arginine glutamate to LOLA. The two groups showed comparable reductions in blood ammonia levels and improvements in time to complete NCT\u2010A. The rate of adverse events was similar between the two groups, with only four cases reported adverse drug reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both regimens effectively alleviated mild HE symptoms and reduced ammonia levels. Arginine glutamate showed non\u2010inferiority to LOLA in terms of clinical improvement, ammonia reduction, and time to complete NCT\u2010A, with no significant adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13355","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T01:25:10Z","timestamp":1750641910000},"page":"241-249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Open\u2010Label Randomized Controlled Non\u2010Inferiority Trial of Arginine Glutamate Injection for the Treatment of Mild Hepatic Encephalopathy"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4505-2827","authenticated-orcid":false,"given":"Hai Bo","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Beijing Tongren Hospital, Capital Medical University  Beijing 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