{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T06:59:28Z","timestamp":1758351568395,"version":"3.44.0"},"reference-count":34,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to investigate the prevalence of alexithymia in patients with functional defecation disorder (FDD) and its impact on treatment outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>FDD patients who underwent high\u2010resolution anorectal manometry and balloon expulsion test were enrolled. Symptoms, anorectal function, and treatment efficacy were assessed at baseline and after 4\u2010week medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Alexithymia was present in 29.5% of all 129 FDD patients. Compared to the non\u2010alexithymia group, the alexithymia group had higher baseline scores for the Patient Assessment of Constipation\u2010Symptoms (PAC\u2010SYM) (19.0 vs. 15.0, <jats:italic>p<\/jats:italic>\u2009=\u20090.03), Patient Assessment of Constipation\u2010Quality of Life (PAC\u2010QOL) (67.0 vs. 26.0, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), Zung's Self\u2010Rating Anxiety Scale (SAS) (44.5 vs. 30.0, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and Self\u2010Rating Depression Scale (SDS) (48.0 vs. 33.0, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Moreover, the improvements in post\u2010treatment complete spontaneous bowel movements (CSBMs) (0.0 vs. 1.5, <jats:italic>p<\/jats:italic>\u2009=\u20090.041), PAC\u2010SYM (0.0 vs. \u221211.5, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), PAC\u2010QOL (0.0 vs. \u221216.0, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), SAS (0.0 vs. \u22121.0, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and SDS (0.0 vs. \u22123.0, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) scores were less significant in the alexithymia group than in the non\u2010alexithymia group. A high Toronto Alexithymia Scale\u201020 score was an independent risk factor for drug therapy failure in FDD patients (odds ratio 0.949, 95% confidence interval 0.919\u20130.980, <jats:italic>p<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Alexithymia is prevalent in FDD patients and significantly affects symptom severity, quality of life, mental state, and treatment outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13356","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T04:50:15Z","timestamp":1750395015000},"page":"212-220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alexithymia in Functional Defecation Disorder: The Incidence and the Effect on Treatment"],"prefix":"10.1111","volume":"26","author":[{"given":"Sai Nan","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital with Nanjing Medical University  Nanjing Jiangsu Province China"},{"name":"Department of Gastroenterology Nantong Haimen People's Hospital  Nantong Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin Bin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital with Nanjing Medical University  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital with Nanjing Medical University  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital with Nanjing Medical University  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5799-9220","authenticated-orcid":false,"given":"Liu Qin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital with Nanjing Medical University  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2020.1708718"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301181"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10092027"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.141.6.725"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000287386"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.032"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32115-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2007.05.016"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.03.035"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13679"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14335"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.08.034"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001647"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2018.27"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655299750025327"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510012208"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073191107306140"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15243"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(71)71479-0"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1965.01720310065008"},{"issue":"9","key":"e_1_2_7_23_1","first-page":"577","article-title":"Chinese Expert Consensus on Chronic Constipation (2019, Guangzhou)","volume":"39","author":"Neurogastroenterology and Motility Committee, Chinese Society of Gastroenterology","year":"2019","journal-title":"Chinese Journal of Digestion"},{"issue":"12","key":"e_1_2_7_24_1","first-page":"828","article-title":"Efficacy and Influencing Factors of Linaclotide in Functional Defecation Disorders","volume":"43","author":"Feng B. 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