{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:46:36Z","timestamp":1758282396084,"version":"3.44.0"},"reference-count":26,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":92,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000533","82100633"],"award-info":[{"award-number":["82000533","82100633"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Fenofibrate is widely used as add\u2010on therapy for patients with primary biliary cholangitis (PBC) who have a suboptimal response to ursodeoxycholic acid (UDCA). We aimed to evaluate whether the UDCA biochemical response criteria, especially the GLOBE and UK\u2010PBC risk scoring systems, could predict the long\u2010term prognosis of PBC patients who received fenofibrate add\u2010on therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PBC patients receiving fenofibrate add\u2010on therapy were included in this retrospective\u2013prospective study. We compared the utility of nine biochemical response criteria and two scoring systems to predict clinical outcomes by Kaplan\u2013Meier plots and the receiver operating characteristic (ROC) curve analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010three patients were included in this study, of whom 11 had a poor outcome (hepatic decompensation, liver\u2010related death, or liver transplantation) and 52 had a good outcome. After a median follow\u2010up of 45\u2009months, fenofibrate add\u2010on therapy steadily decreased the serum levels of alkaline phosphatase, \u03b3\u2010glutamyl transferase, and alanine aminotransferase in both groups. The patients with poor outcomes had a higher GLOBE score and UK\u2010PBC risk score than those with good outcomes after 12\u2009months of treatment. More importantly, both scores had better predictive performance for hepatic decompensation\u2010 and transplant\u2010free survival than the other criteria. The areas under the ROC curve of the GLOBE and UK\u2010PBC risk scores at 12\u2009months were 0.878 (95% confidence interval [CI] 0.751\u20130.955) and 0.919 (95% CI 0.803\u20130.978), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The GLOBE and UK\u2010PBC risk scores outperformed the other biochemical response criteria in predicting the clinical outcomes of PBC patients with suboptimal response to UDCA and receiving fenofibrate add\u2010on therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13359","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T15:02:36Z","timestamp":1754060556000},"page":"250-259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>GLOBE<\/scp> Score and <scp>UK<\/scp>\u2010<scp>PBC<\/scp> Risk Score Predict Long\u2010Term Clinical Outcomes of Patients With Primary Biliary Cholangitis and Receiving Ursodeoxycholic Acid and Fenofibrate"],"prefix":"10.1111","volume":"26","author":[{"given":"Shu Xiang","family":"Li","sequence":"first","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital Capital Medical University  Beijing China"},{"name":"State Key Laboratory of Digestive Health  Beijing China"},{"name":"National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bu Er","family":"Li","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital Capital Medical University  Beijing China"},{"name":"State Key Laboratory of Digestive Health  Beijing China"},{"name":"National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology and EBM, Beijing Friendship Hospital Capital Medical 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