{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:11:54Z","timestamp":1793913114883,"version":"4.8.0"},"reference-count":46,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":48,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1A6A1A03044296"],"award-info":[{"award-number":["2021R1A6A1A03044296"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy and safety of tegoprazan (TPZ) compared to conventional proton pump inhibitors (PPIs) for <jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter pylori<\/jats:italic><\/jats:styled-content> eradication as first\u2010 and second\u2010line therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four databases were searched for randomized controlled trials (RCTs) and retrospective studies comparing TPZ\u2010 and PPI\u2010based regimens for <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> eradication published until October 15, 2024. A random\u2010effects model was used to calculate pooled odds ratio (OR) and 95% confidence interval (CI) based on intention\u2010to\u2010treat and per\u2010protocol analyses. The PROSPERO registration number of the study is CRD42024622705.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine studies (three RCTs and six retrospective studies) involving 5228 treatment\u2010na\u00efve patients were included. TPZ was non\u2010inferior to PPIs as a first\u2010line therapy (intention\u2010to\u2010treat: odds ratio [OR] 1.066, 95% confidence interval [CI] 0.929\u20131.224; per\u2010protocol: OR 1.142, 95% CI: 0.967\u20131.349). Subgroup analyses showed no significant differences based on study design, therapeutic regimen, or treatment duration. In patients with clarithromycin\u2010resistant strains confirmed by 23S rRNA sequencing, TPZ achieved a higher eradication rate (OR 4.961, 95% CI 1.024\u201324.030). TPZ was associated with significantly lower odds of abdominal discomfort compared to PPIs (OR 0.490, 95% CI 0.268\u20130.897). Regarding treatment duration, a 14\u2010day regimen was linked to a lower risk of diarrhea, while a 7\u2010day regimen was associated with a higher risk of abdominal pain. No significant differences were observed in second\u2010line therapeutic outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TPZ represents a non\u2010inferior alternative to PPIs for <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> eradication, with potential benefits in clarithromycin\u2010resistant infections and favorable safety profiles. Future studies are warranted to assess higher dosages and address pharmacokinetic limitations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.70004","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T06:11:10Z","timestamp":1755583870000},"page":"305-317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Tegoprazan as First\u2010 and Second\u2010Line Therapy for Eradication of <scp><i>Helicobacter pylori<\/i><\/scp> Infection: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6507-915X","authenticated-orcid":false,"given":"Sujata","family":"Purja","sequence":"first","affiliation":[{"name":"Data Science, Evidence\u2010Based and Clinical Research Laboratory, Department of Health, Social, and Clinical Pharmacy College of Pharmacy, Chung\u2010Ang University  Seoul Republic of Korea"},{"name":"Central 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