{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:40:38Z","timestamp":1790858438995,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"9-10","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Upadacitinib (UPA) and vedolizumab (VDZ) have been approved to treat moderate\u2010to\u2010severe ulcerative colitis (UC); however, direct comparative data between these two regimens are lacking. We aimed to compare the effectiveness and safety of UPA and VDZ among patients with moderate\u2010to\u2010severe UC who had previously been treated with advanced therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with moderate\u2010to\u2010severe UC receiving VDZ or UPA for at least 14\u2009weeks following advanced therapy failure, including at least one anti\u2010tumor necrosis factor (TNF) agent, between 2015 and 2024, were retrospectively recruited. Clinical response and remission were defined by the Partial Mayo Score and the Simple Clinical Colitis Activity Index. The safety profile during the treatment was also compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Altogether 66 patients treated with VDZ and 22 patients with UPA were included. The median age of the VDZ and UPA groups was 38 and 37\u2009years, respectively. Patients receiving UPA achieved significantly higher rates of corticosteroid\u2010free remission after 52\u2010week therapy (75.0% vs. 25.0%; adjusted odds ratio [aOR] 5.68, 95% confidence interval [CI] 1.50\u201321.00,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011); however, these patients were more likely to experience adverse events (AEs) (40.9% vs. 9.1%; aOR 4.60, 95% CI 1.20\u201317.00,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), although medication discontinuation due to AEs was only noted in two (3.0%) patients receiving VDZ. No patients were hospitalized during the treatment period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>UC patients receiving UPA achieved significantly higher rates of corticosteroid\u2010free clinical remission but with more AEs, suggesting that decision\u2010making based on disease severity and comorbidities can help guide the positioning of these therapies in UC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1751-2980.70012","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T06:59:59Z","timestamp":1760079599000},"page":"428-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Effectiveness and Safety of Upadacitinib and Vedolizumab in Biologic\u2010Experienced Patients With Ulcerative Colitis: A Retrospective Study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3584-1195","authenticated-orcid":false,"given":"Neta","family":"Sror","sequence":"first","affiliation":[{"name":"Department of Internal Medicine B Tel Aviv Sourasky Medical Center  Tel\u2010Aviv Israel"},{"name":"Affiliated With the Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4172-6903","authenticated-orcid":false,"given":"Haim","family":"Leibovitzh","sequence":"additional","affiliation":[{"name":"Affiliated With the Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"IBD Center, Department of Gastroenterology and Liver Diseases Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayal","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Affiliated With the Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"IBD Center, Department of Gastroenterology and Liver Diseases Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Thurm","sequence":"additional","affiliation":[{"name":"Affiliated With the Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"IBD Center, Department of Gastroenterology and Liver Diseases Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia","family":"Ron","sequence":"additional","affiliation":[{"name":"Affiliated With the Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"IBD Center, Department of Gastroenterology and Liver Diseases Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitsan","family":"Maharshak","sequence":"additional","affiliation":[{"name":"Affiliated With the Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"IBD Center, Department of Gastroenterology and Liver Diseases Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel Aviv","family":"Cohen","sequence":"additional","affiliation":[{"name":"Affiliated With the Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"IBD Center, Department of Gastroenterology and Liver Diseases Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab178"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjw092"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41927\u2010018\u20100031\u2010x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1905725"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-024-02912-y"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.07.046"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-326390"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00377-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.08.027"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.04.038"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508865"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002746"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.007"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000669"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000533871"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17961"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.15389"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106359"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.001"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.03.001"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/crocol\/otad009"}],"container-title":["Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.70012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T23:26:03Z","timestamp":1765063563000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1751-2980.70012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":21,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/1751-2980.70012"],"URL":"https:\/\/doi.org\/10.1111\/1751-2980.70012","archive":["Portico"],"relation":{},"ISSN":["1751-2972","1751-2980"],"issn-type":[{"value":"1751-2972","type":"print"},{"value":"1751-2980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}