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Ubiquitination, a crucial post\u2010translational modification, plays a significant role in the initiation and progression of UC. Gaining a deeper understanding of the molecular mechanisms underlying ubiquitination may help establish novel therapeutic strategies for UC. This review emphasizes the role of ubiquitination in regulating the intestinal epithelial barrier, nuclear factor (NF)\u2010\u03baB signaling, and immune responses, with the aim of providing new perspectives and potential directions for targeted therapies in UC.<\/jats:p>","DOI":"10.1111\/1751-2980.70017","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T14:05:24Z","timestamp":1763129124000},"page":"398-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Regulatory Role of Protein Ubiquitination in the Pathogenesis and Progression of Ulcerative Colitis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9872-0951","authenticated-orcid":false,"given":"Ya Long","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union 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