{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:19:37Z","timestamp":1790288377405,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":75,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Juvenile spondyloarthritis (JSpA) shares genetic, immunopathogenic, and environmental features with pediatric inflammatory bowel disease (IBD), placing patients at an elevated risk for IBD. We aimed to evaluate the prevalence of IBD and identify potential early markers for its recognition in children with JSpA, trying to improve its diagnostic, screening, and treatment strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children diagnosed with JSpA were prospectively evaluated. Fecal calprotectin (FCP) was measured in all participants, and those with elevated FCP (&gt;\u2009100\u2009\u03bcg\/g) or two or more IBD\u2010related symptoms (chronic diarrhea, weight loss\/growth retardation, abdominal pain, or bloody\/mucous stool) underwent ileocolonoscopy with histopathological and radiological assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Altogether 81 children (71.6% male) with a mean age of 194\u2009months at adimission\u00a0were included, and 23 underwent endoscopic evaluation (19 for elevated FCP, 4 for two or more IBD\u2010related symptoms). Among them, 10 (43.5%) had both macroscopic and microscopic presentation of colitis, 4 (17.4%) had microscopic appearance only, and 9 (39.1%) had normal histopathological findings. Notably, 94.7% of children with elevated FCP levels were asymptomatic for IBD. Among FCP\u2010positive patients, 13 (68.4%) showed macroscopic and\/or microscopic mucosal changes. Overall, colitis was confirmed in 14 (17.3%) patients. Sacroiliitis, as confirmed by magnetic resonance imaging, was significantly more frequent among both FCP\u2010positive and colitis\u2010positive patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008, respectively). No significant associations were found between FCP levels or intestinal inflammation and disease activity, acute\u2010phase reactants, or treatment status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IBD and subclinical colitis are relatively frequent in JSpA. Elevated FCP represents a promising noninvasive biomarker for detecting silent intestinal inflammation, warranting confirmation by ileocolonoscopy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1751-2980.70028","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T05:01:13Z","timestamp":1768539673000},"page":"518-529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Prevalence of Inflammatory Bowel Disease in Juvenile Spondyloarthritis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4517-0148","authenticated-orcid":false,"given":"Ipek","family":"Ulkersoy","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition Cerrahpasa Faculty of Medicine, Istanbul University\u2010Cerrahpasa  Istanbul 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University\u2010Cerrahpasa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2227-5200","authenticated-orcid":false,"given":"Nursena Kologlu","family":"Ates","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition Cerrahpasa Faculty of Medicine, Istanbul University\u2010Cerrahpasa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8174-5308","authenticated-orcid":false,"given":"Elif Kilic","family":"Konte","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology Cerrahpasa Faculty of Medicine, Istanbul University\u2010Cerrahpasa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0137-0460","authenticated-orcid":false,"given":"Aybuke","family":"Gunalp","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology Cerrahpasa Faculty of Medicine, Istanbul University\u2010Cerrahpasa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7554-3320","authenticated-orcid":false,"given":"Esma","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology Cerrahpasa Faculty of Medicine, Istanbul University\u2010Cerrahpasa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8433-1883","authenticated-orcid":false,"given":"Ayse Kalyoncu","family":"Ucar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology Cerrahpasa Faculty of Medicine, Istanbul University\u2010Cerrahpasa  Istanbul 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