{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:03:49Z","timestamp":1777903429936,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470664"],"award-info":[{"award-number":["82470664"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370636"],"award-info":[{"award-number":["82370636"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170629"],"award-info":[{"award-number":["82170629"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474419"],"award-info":[{"award-number":["82474419"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20654"],"award-info":[{"award-number":["U24A20654"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170602"],"award-info":[{"award-number":["82170602"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870425"],"award-info":[{"award-number":["81870425"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2301800"],"award-info":[{"award-number":["2021YFC2301800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2304500"],"award-info":[{"award-number":["2022YFC2304500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2305100"],"award-info":[{"award-number":["2022YFC2305100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Discharged cirrhotic patients hospitalized for acute decompensation (AD) without acute\u2010on\u2010chronic liver failure (ACLF) have heterogeneous long\u2010term prognosis; however, reliable prognostic tools are lacking. We aimed to identify the risk factors associated with 1\u2010year adverse outcomes including mortality and liver transplantation (LT) after patient\u2019s discharge and to develop an evidence\u2010based prognostic model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 1212 and 621 cirrhotic patients who clinically improved after AD without ACLF before discharge from the Chinese AcuTe\u2010on\u2010CHronic LIver FailurE (CATCH\u2010LIFE) derivation and validation cohorts, respectively. The primary outcome was 1\u2010year adverse outcomes (all\u2010cause mortality or LT) post\u2010discharge. Independent risk factors for 1\u2010year post\u2010discharge adverse outcomes were identified using multivariable analysis, and a prognostic model was derived and validated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the derivation cohort, 203 (16.7%) patients experienced 1\u2010year adverse outcomes and 370 (30.5%) were readmitted within 90\u2009days post\u2010discharge. Age, prior decompensation, total bilirubin, international normalized ratio, albumin, and hemoglobin on discharge were independently associated with 1\u2010year post\u2010discharge adverse outcomes. The prognostic model achieved an area under the receiver operating characteristic curve (AUC) of 0.7767 (95% confidence interval [CI] 0.7408\u20130.8125) and 0.7274 (95% CI 0.6656\u20130.7892) in the derivation and validation cohorts. Using a risk threshold of \u2265\u20090.27, 17.70% of discharged non\u2010ACLF cirrhotic patients with AD in the validation cohort were classified as high\u2010risk, with 1\u2010year adverse outcome rate being 43.96%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A prognostic model for predicting 1\u2010year adverse outcomes in discharged non\u2010ACLF cirrhotic patients was developed and validated, with a high\u2010risk cut\u2010off \u2265\u20090.27, which may effectively stratify adverse outcome risks at 1\u2010year post\u2010discharge and guide intensive post\u2010discharge management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1751-2980.70039","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:35:02Z","timestamp":1772984102000},"page":"63-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Prognostic Score for 1\u2010Year Adverse Outcomes in Non\u2010\n                    <scp>ACLF<\/scp>\n                    Cirrhotic Patients After Discharge: A Multicenter Prospective Cohort Study"],"prefix":"10.1111","volume":"27","author":[{"given":"Yue Xiang","family":"Bian","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease NHC Key Laboratory of Digestive Diseases  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease NHC Key Laboratory of Digestive Diseases  Shanghai China"},{"name":"Department of Gastroenterology and Hepatology Kashgar Prefecture Second People's Hospital  Kashgar Xinjiang Uygur Autonomous Region China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Integrative Medicine, Beijing Ditan Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6564-7807","authenticated-orcid":false,"given":"Xin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Institute of Infection and Immunology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen Ting","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu Hua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hunan Key Laboratory of Viral Hepatitis, Xiangya Hospital of Central South University  Changsha Hunan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong Ji","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Hubei Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer, Taihe Hospital Hubei University of Medicine  Shiyan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan Hang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Hepatology The First Hospital of Jilin University  Changchun Jilin Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi Ping","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Liver Intensive Care Unit Shanghai Public Health Clinical Center, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Hepatology Nankai University Second People's Hospital  Tianjin China"},{"name":"Department of Infectious Diseases and Hepatology The Second Qilu Hospital of Shandong University  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Bo","family":"Lu","sequence":"additional","affiliation":[{"name":"Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical University  Urumqi Xinjiang Uygur Autonomous Region China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9392-7176","authenticated-orcid":false,"given":"Yu","family":"Shi","sequence":"additional","affiliation":[{"name":"The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang Province China"},{"name":"Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease  Hangzhou Zhejiang Province China"},{"name":"National Clinical Research Center of Infectious Disease  Hangzhou Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2630-2563","authenticated-orcid":false,"given":"Yu Bao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying Li","family":"He","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian Yi","family":"Wei","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease NHC Key Laboratory of Digestive Diseases  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei Xuan","family":"Ji","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease NHC Key Laboratory of Digestive Diseases  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"He","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease NHC Key Laboratory of Digestive Diseases  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adila","family":"Abuduaini","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease NHC Key Laboratory of Digestive Diseases  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya Wen","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease NHC Key Laboratory of Digestive Diseases  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kashgar Prefecture Second People's Hospital  Kashgar Xinjiang Uygur Autonomous Region China"},{"name":"Department of Gastroenterology and Hepatology, Shanghai General Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease NHC Key Laboratory of Digestive Diseases  Shanghai China"},{"name":"Department of Gastroenterology, Punan Branch of Renji Hospital School of Medicine, Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Chinese (Acute on) Chronic Liver Failure Consortium (Ch\u2010CLIF.C)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60121-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1504367"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00759-2"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.06.018"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.02.042"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.06.013"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12089"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15734"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100529"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.01.027"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2023.100698"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-024-08406-9"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000971"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.11.012"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwy083"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102020\u2010037793"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.41"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.05.042"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.05.004"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.02.010"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.22172"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.02.010"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.08.050"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.143.1.7063747"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.12126"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2015.12.005"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/goz062"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.314"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14054"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.07.011"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.646875"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/poh2.53"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.07.008"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2023.100688"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13968"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2023.100785"}],"container-title":["Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.70039","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1751-2980.70039","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.70039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:58:55Z","timestamp":1777636735000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1751-2980.70039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":37,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/1751-2980.70039"],"URL":"https:\/\/doi.org\/10.1111\/1751-2980.70039","archive":["Portico"],"relation":{},"ISSN":["1751-2972","1751-2980"],"issn-type":[{"value":"1751-2972","type":"print"},{"value":"1751-2980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}