{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:28:21Z","timestamp":1787164101214,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":102,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903398"],"award-info":[{"award-number":["81903398"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2026NSFSC0589"],"award-info":[{"award-number":["2026NSFSC0589"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2023NSFSC1927"],"award-info":[{"award-number":["2023NSFSC1927"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Gallstone disease (GSD), a prevalent digestive disorder, remains mechanistically underexplored in relation to visceral adipose. The Metabolic Score for Visceral Fat (METS\u2010VF), a novel metric for quantifying visceral adipose tissue, has not yet been evaluated for its association with GSD in cohort studies. We aimed to investigate the METS\u2010VF\u2013GSD association across multicenter cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multicenter cohort analysis of 59\u2009851 participants from two Chinese hospitals and 357\u2009233 participants from the UK Biobank dataset was conducted using Cox models to investigate the association between METS\u2010VF and GSD risk. Competing risk models were also applied to the UK Biobank cohort. Meta\u2010analysis and mediation analysis were used to synthesize results from the cohort analysis and evaluate mediation effects of inflammatory biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cox models revealed a significant positive association between METS\u2010VF and GSD risk, with a \u201cJ\u2010shaped\u201d nonlinearity, as confirmed by restricted cubic spline analysis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Meta\u2010analysis revealed that for each 1\u2010unit and 1\u2010standard deviation increase in METS\u2010VF, GSD risk increased by 84% and 57%, respectively. Compared with participants in quantile 1 (Q1) of METS\u2010VF, those in Q2 (pooled hazard ratio [HR] 1.65, 95% confidence interval [CI] 1.35\u20132.01), Q3 (pooled HR 2.16, 95% CI 1.83\u20132.54), and Q4 (pooled HR 3.00, 95% CI 2.82\u20133.19) were associated with progressively higher GSD risk. Mediation analysis revealed that certain inflammatory biomarkers partially mediated the effect of METS\u2010VF on incident GSD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Increased METS\u2010VF is associated with a higher risk of GSD. It may serve as an important indicator for identifying high\u2010risk populations for GSD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1751-2980.70044","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T10:29:33Z","timestamp":1776076173000},"page":"87-98","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metabolic Score for Visceral Fat and Gallstone Disease Risk: A Multicenter Cohort Study and Mediation Analysis of Inflammatory Biomarkers"],"prefix":"10.1111","volume":"27","author":[{"given":"Cui Hua","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics West China School of Public Health and West China Fourth Hospital, Sichuan University  Chengdu Sichuan Province China"},{"name":"Health Promotion and Food Nutrition &amp; Safety Key Laboratory of Sichuan Province  Chengdu Sichuan Province 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