{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:03:45Z","timestamp":1777903425724,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":90,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103902"],"award-info":[{"award-number":["82103902"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019398","name":"Beijing Friendship Hospital, Capital Medical University","doi-asserted-by":"publisher","award":["yyqcjh2023\u20109"],"award-info":[{"award-number":["yyqcjh2023\u20109"]}],"id":[{"id":"10.13039\/501100019398","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine whether baseline levels and short\u2010term changes of asymmetric dimethylarginine (ADMA) are associated with subclinical carotid atherosclerosis (SCA) and its progression in adults with metabolic dysfunction\u2013associated steatotic liver disease (MASLD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 600 adults with MASLD were prospectively recruited and followed annually for 2\u2009years. Serum ADMA was measured at baseline and 1\u2010year follow\u2010up. SCA, defined as increased carotid intima\u2010media thickness or carotid plaque, was assessed at baseline, 1\u2010 and 2\u2010year follow\u2010up. Multivariable regression and propensity score\u2010based analyses were performed to assess the associations between baseline ADMA or change in ADMA and SCA risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Increased baseline ADMA level was significantly associated with SCA. Each 1\u2010standard deviation (SD) increase in baseline ADMA was associated with higher odds of SCA (odds ratio 2.24, 95% confidence interval [CI] 1.66\u20133.01), with a dose\u2013response relationship across ADMA quartiles. Baseline ADMA was not associated with SCA progression; however, dynamic increase in ADMA over time was strongly associated with SCA progression at both 1 and 2\u2009years. Each 1\u2010SD increase in absolute and relative changes of ADMA was associated with higher risks of SCA progression at 1\u2009year (relative risk [RR] 1.82, 95% CI 1.60\u20132.07; RR 1.44, 95% CI 1.29\u20131.61) and 2\u2009years (RR 1.52, 95% CI 1.36\u20131.70; RR 1.31, 95% CI 1.20\u20131.42). Associations were more pronounced among participants with pre\u2010existing\u00a0SCA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ADMA is associated with the prevalence of SCA, and short\u2010term dynamic changes in ADMA may represent early indicators for SCA progression in adults with MASLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1751-2980.70045","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T08:05:41Z","timestamp":1775030741000},"page":"75-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Asymmetric Dimethylarginine, Its Change, and Subclinical Carotid Atherosclerosis in Metabolic Dysfunction\u2013Associated Steatotic Liver Disease"],"prefix":"10.1111","volume":"27","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin Tian","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and EBM Unit, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1465-5310","authenticated-orcid":false,"given":"Peng Fei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting Ting","family":"Lyu","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan Fang","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and EBM Unit, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin Yan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9595-5536","authenticated-orcid":false,"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and EBM Unit, Beijing Friendship Hospital Capital Medical University  Beijing 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