{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:56:23Z","timestamp":1781880983630,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":81,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Vonoprazan was approved in China for reflux esophagitis (RE) in 2019; however, its real\u2010world safety and effectiveness remain undetermined. We aimed to evaluate the safety of vonoprazan in patients and its effectiveness in patients with RE in a real\u2010world setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective, non\u2010interventional, real\u2010world study, vonoprazan 20\u2009mg was administered orally daily for 4 or 8\u2009weeks. Primary endpoints were incidence rates of adverse events (AEs), serious AEs (SAEs), and adverse drug reactions (ADRs). Secondary endpoints included proportions of patients with RE without typical gastroesophageal reflux disease (GERD) symptoms (complete symptom relief) at baseline and Week 4, relief of heartburn\/regurgitation symptoms (all day\/nighttime) during Week 1, and mean change in GERD Questionnaire (GERDQ) score at Week 4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 2829 patients with safety data, 488 (17.2%) reported \u2265\u20091 AE; 29 (1.0%) reported \u2265\u20091 SAE; and 129 (4.6%) reported \u2265\u20091 ADR. Of 1796 patients with RE and effectiveness data, the proportion without typical symptoms of GERD increased from 20.1% (95% confidence interval [CI] 18.29\u201322.05) at baseline to 55.2% (95% CI 52.63\u201357.79) at Week 4 (change: 35.1%, 95% CI 31.95\u201338.25). Complete relief from heartburn, nighttime heartburn, regurgitation, and nighttime regurgitation was observed in 32.3% (314\/971), 43.8% (427\/975), 27.0% (262\/971), and 40.5% (395\/976) patients, respectively, during Week 1. Mean change in GERDQ score (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091464) improved by Week 4 (\u22121.70).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vonoprazan is well tolerated through 8\u2009weeks in patients and improves symptoms in patients with RE in the real\u2010world setting in China (VIEW; NCT04501627).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1751-2980.70051","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T03:09:08Z","timestamp":1779419348000},"page":"150-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Safety of Vonoprazan in Patients and Symptom Outcomes in Patients With Reflux Esophagitis in China: A Prospective, Non\u2010Interventional Study (\n                    <scp>VIEW<\/scp>\n                    )"],"prefix":"10.1111","volume":"27","author":[{"given":"Ying Lian","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Second Affiliated Hospital of Guangzhou Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Xia","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Heilongjiang Provincial Hospital  Harbin Heilongjiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3821-9342","authenticated-orcid":false,"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology West China Hospital, Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo Liang","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Ningbo University  Ningbo Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Song","sequence":"additional","affiliation":[{"name":"China Medical Team, Takeda (China) International Trade Co., Ltd.  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Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Hu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i45.8391"},{"key":"e_1_2_9_3_1","volume-title":"StatPearls [Internet]","author":"Goosenberg E.","year":"2026"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001538"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2010.09.008"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.08.1458"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e328332ca2f"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32835ae8f7"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1756-4594"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913\u2010024\u201011781\u20108"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2010.521888"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318365"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000854"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13461"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2018.03.004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.0349"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050111"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2005.pto_273.x"},{"issue":"1","key":"e_1_2_9_19_1","article-title":"Shortcomings of the First\u2010Generation Proton Pump Inhibitors","volume":"13","author":"Tytgat G. 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