{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:58:07Z","timestamp":1781881087163,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":80,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100023322","name":"Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Szegedi Tudom\u00e1nyegyetem","doi-asserted-by":"publisher","award":["IV\u2010114\u20101\/2026.SZAOK"],"award-info":[{"award-number":["IV\u2010114\u20101\/2026.SZAOK"]}],"id":[{"id":"10.13039\/501100023322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["BO\/00340\/25"],"award-info":[{"award-number":["BO\/00340\/25"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015763","name":"Szegedi Tudom\u00e1nyegyetem","doi-asserted-by":"publisher","award":["8539"],"award-info":[{"award-number":["8539"]}],"id":[{"id":"10.13039\/501100015763","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Long\u2010standing inflammatory bowel disease (IBD) increases the risk of dysplasia and colorectal cancer (CRC), particularly in patients with extensive disease or coexisting primary sclerosing cholangitis (PSC). Several non\u2010conventional dysplasia subtypes have been identified. Hypermucinous dysplasia was first formally proposed in 2020, and it arises predominantly in patients with long\u2010standing ulcerative colitis, frequently in extensive disease and concomitant PSC. Histologically, hypermucinous dysplasia is characterized by a tubulovillous or villous architecture lined by tall, prominent, mucin\u2010rich epithelial cells comprising more than 50% of the lesion, with minimal\u2010to\u2010mild cytologic atypia. Although often classified as low\u2010grade dysplasia according to previously established criteria, hypermucinous dysplasia is disproportionately associated with advanced neoplasia, including high\u2010grade dysplasia and CRC, and frequently coexists with both conventional and other non\u2010conventional dysplasias. Molecular alterations commonly include aneuploidy and occasional\n                    <jats:italic>TP53<\/jats:italic>\n                    mutation. Emerging evidence suggests that non\u2010dysplastic, mucin\u2010rich epithelial proliferation, such as hypermucinous mucosa and foveolar metaplasia, may represent putative precursor lesions within a broader metaplasia\u2013dysplasia sequence. This review provides the first comprehensive synthesis focusing exclusively on hypermucinous dysplasia, highlighting the consistency in histopathologic definitions, proposed precursor lesions, clinicopathological associations, molecular features, and diagnostic reproducibility. Increased awareness of hypermucinous dysplasia is essential for accurate diagnosis, risk stratification, high\u2010risk IBD population screening, and optimal management of patients with IBD.\n                  <\/jats:p>","DOI":"10.1111\/1751-2980.70052","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:47:45Z","timestamp":1779342465000},"page":"110-117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypermucinous Dysplasia in Inflammatory Bowel Disease (\n                    <scp>IBD<\/scp>\n                    ): Morphology, Molecular Features, and Its Place in the\n                    <scp>IBD<\/scp>\n                    \u2010Associated Neoplastic Spectrum"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3262-8567","authenticated-orcid":false,"given":"\u00c1d\u00e1m","family":"Ferenczi","sequence":"first","affiliation":[{"name":"Department of Pathology University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Lantos","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Informatics University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9434-2989","authenticated-orcid":false,"given":"Anita","family":"Sejben","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/pore.2024.1611978"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/pore.2025.1612105"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp-2023-209206"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjac090"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2019.01.010"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e31828dcaaf"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2015.1121364"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2023.11.011"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001330"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14549"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(83)80175-0"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.01.031"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14298"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0419-1"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab120"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002217"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.5.686"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-019-02627-4"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13027\u2010017\u20100172\u20103"},{"issue":"2","key":"e_1_2_10_21_1","first-page":"481","article-title":"Hypermucinous Dysplasia in Inflammatory Bowel Disease: A Heterogeneous Condition with Frequent Foveolar Differentiation","volume":"35","author":"K\u0151v\u00e1ri B.","year":"2022","journal-title":"Modern Pathology"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14765"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14922"},{"issue":"51","key":"e_1_2_10_24_1","first-page":"2039","article-title":"Hypermucinous and Goblet Cell\u2010Deficient, IBD\u2010Associated, Non\u2010Conventional Dysplasia Besides Colorectal Adenocarcinoma","volume":"164","author":"Alm\u00e1si S.","year":"2023","journal-title":"Orvosi 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