{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:59:22Z","timestamp":1789750762101,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":106,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Comparative data on infliximab (IFX) and tacrolimus as salvage therapies for intravenous glucocorticoid (ivGC)\u2010refractory acute severe ulcerative colitis (ASUC) are limited. We aimed to evaluate the effectiveness and safety of IFX versus tacrolimus in hospitalized patients with ivGC\u2010refractory ASUC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study was conducted between 2017 and 2024 at a tertiary medical center, including inpatients with ASUC who failed ivGC and received IFX or tacrolimus. The primary outcome was colectomy\u2010free clinical response at discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010seven patients received IFX (median age 27\u2009years; 32.4% males), and 24 received tacrolimus (median age 32\u2009years; 41.7% males). Compared with the patients who received IFX, those receiving tacrolimus had a longer disease duration (4\u2009years vs. 1 year,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031) and a higher rate of prior exposure to advanced therapy (anti\u2010tumor necrosis factor agent: 58.3% vs. 2.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.05\u2009\u00d7\u200910\n                      <jats:sup>\u22126<\/jats:sup>\n                      ; Janus kinase inhibitors: 20.8% vs. 0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). The length of hospitalization was significantly longer among those receiving tacrolimus (median 19.5\u2009days vs. 11.0 days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019). Colectomy\u2010free clinical response rate at discharge (81.1% vs. 83.3%, multivariate analysis\n                      <jats:italic>p<\/jats:italic>\n                      = 0.956) and total colectomy rate in the following year (12.5% vs. 14.3%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.851) did not significantly differ between the IFX and tacrolimus groups. Safety profile during hospitalization was comparable between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In ivGC\u2010refractory ASUC cases, IFX and tacrolimus showed comparable effectiveness and safety. Similar outcomes were observed despite a more treatment\u2010refractory profile in the tacrolimus group. These findings support the use of either agent as a feasible salvage option in this clinical setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1751-2980.70055","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:25:59Z","timestamp":1781587559000},"page":"160-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Tacrolimus and Infliximab for Acute Severe Ulcerative Colitis in Hospitalized Adults: A Retrospective Study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3584-1195","authenticated-orcid":false,"given":"Neta","family":"Sror","sequence":"first","affiliation":[{"name":"Department of Internal Medicine B Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Tamir\u2010Degabli","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"IBD Center, Department of Gastroenterology and Liver Diseases Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Shaham","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Rozenfeld","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"IBD Center, Department of Gastroenterology and Liver Diseases Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4172-6903","authenticated-orcid":false,"given":"Haim","family":"Leibovitzh","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"IBD Center, Department of Gastroenterology and Liver Diseases Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayal","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"IBD Center, Department of Gastroenterology and Liver Diseases Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Thurm","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"IBD Center, 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