{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:07:25Z","timestamp":1788941245386,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":76,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270570"],"award-info":[{"award-number":["82270570"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070551"],"award-info":[{"award-number":["82070551"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the clinical practice and quality of first\u2010line\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Helicobacter pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication therapy by gastroenterologists in direct\u2010to\u2010consumer telemedicine (DTCT) settings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The study was conducted between November 2024 and February 2025 using unannounced standardized patients (USPs). Six trained and validated USPs questioned clinicians using specific\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H.\u2009pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection scenarios on hospital\u2010 or enterprise\u2010sponsored DTCT platforms. Accessibility and effective consultation rates of the enquiry platforms were evaluated. The consultation process at each visit was also analyzed for guideline adherence and patient\u2010centeredness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      USPs conducted 552 visits on 53 hospital\u2010 and 19 enterprise\u2010sponsored accessible platforms, with effective consultation rate of 65.6% (362 of 552). Based on a 10\u2010point quality checklist, the overall guideline adherence score was 5.0, which was significantly higher for the enterprise\u2010sponsored platforms than for hospital platforms (5.4\u2009\u00b1\u20092.7 vs. 4.8\u2009\u00b1\u20092.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045). When stratified by professional title of the clinicians involved, clinicians with intermediate title achieved a higher guideline adherence score than those with junior or senior titles (5.5\u2009\u00b1\u20092.7 vs. 4.3\u2009\u00b1\u20092.7 vs. 4.8\u2009\u00b1\u20092.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). Altogether 72% of clinicians prescribed\u00a0the correct treatment regimen for\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H.\u2009pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection. Furthermore, patient satisfaction during the treatment process was generally acceptable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      We identified gaps in guideline adherence and clinical standardization for telemedicine\u2010based\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H.\u2009pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication in China. Further nationwide standardized training for gastroenterologists should prioritize structured history\u2010taking, appropriate prescribing, resistance\u2010guided antibiotic selection, and patient follow\u2010up management.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      ID: NCT06749873\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1751-2980.70061","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:17:06Z","timestamp":1784261826000},"page":"205-213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality of\n          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