{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:05:23Z","timestamp":1788973523308,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":102,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The universal adoption of endoscopic submucosal dissection (ESD) is limited by its technical demands, slow learning curve, long procedure time, and high risks of bleeding, muscular layer injury, and perforation. We developed the submucosal pressure ejection endoscopic dissection (SPEED) technique that combines pressure injection, incision, dissection, and coagulation and avoids frequent device exchange during ESD. We aimed to introduce this novel SPEED strategy and evaluate its therapeutic advantages for superficial gastrointestinal neoplasms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Altogether 985 patients who underwent ESD for early gastrointestinal tumors between January 2020 and April 2024 were included and divided into the SPEED group and the conventional ESD group. Clinical outcomes, including en bloc and R0 resection rates, resection time, intraprocedural application of hemostatic forceps, procedure\u2010related adverse events, and local recurrence, were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SPEED achieved en bloc and R0 resection rates of 99.85% and 99.40%, respectively. Compared with conventional ESD, SPEED was associated with a shorter median resection time (33 min vs. 57\u2009min), less frequent intraprocedural application of hemostatic forceps (2.71% vs. 19.25%), a lower intraprocedural perforation rate (0.15% vs. 2.48%), and a lower post\u2010procedure hemorrhage rate (1.51% vs. 5.90%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>With the additional high\u2010pressure injection, the SPEED technique greatly improves ESD efficiency and ensures a clearer visual field during ESD, thereby reducing risk of complications. It efficiently improves the speed and safety of dissection during ESD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1751-2980.70064","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T09:59:20Z","timestamp":1786442360000},"page":"225-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Submucosal Pressure Ejection Endoscopic Dissection (\n                    <scp>SPEED<\/scp>\n                    ): A New Technique in Increasing the Safety and Efficacy of\n                    <scp>ESD<\/scp>\n                    (With Video)"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8016-9732","authenticated-orcid":false,"given":"Tao","family":"Chen","sequence":"first","affiliation":[{"name":"Endoscopy Center, Department of Gastroenterology Shanghai East Hospital, Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu Yun","family":"Leng","sequence":"additional","affiliation":[{"name":"Endoscopy Center, Department of Gastroenterology Shanghai East Hospital, Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"Endoscopy Center, Department of Gastroenterology Shanghai East Hospital, Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing Jing","family":"Lian","sequence":"additional","affiliation":[{"name":"Endoscopy Center, Department of Gastroenterology Shanghai East Hospital, Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Endoscopy Center, Department of Gastroenterology Shanghai East Hospital, Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shen","sequence":"additional","affiliation":[{"name":"Endoscopy Center, Department of Gastroenterology Shanghai East Hospital, Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Shanghai East Hospital, Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7219-5826","authenticated-orcid":false,"given":"Mei Dong","family":"Xu","sequence":"additional","affiliation":[{"name":"Endoscopy Center, Department of Gastroenterology Shanghai East Hospital, Tongji University School of Medicine  Shanghai 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of Perforation Related to Colorectal Endoscopic Submucosal Dissection: Is This Finally Predictable?","volume":"30","author":"Murino A.","year":"2024","journal-title":"Saudi Journal of Gastroenterology"},{"issue":"1","key":"e_1_2_9_15_1","first-page":"E421","article-title":"Pocket\u2010Creation Method of Endoscopic Submucosal Dissection to Achieve En Bloc Resection of Giant Colorectal Subpedunculated Neoplastic Lesions","volume":"46","author":"Hayashi Y.","year":"2014","journal-title":"Endoscopy"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vgie.2023.09.008"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-022-09228-4"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1214473"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2017.108"}],"container-title":["Journal of Digestive 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