{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T16:37:11Z","timestamp":1793205431104,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":64,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Incidental diagnosis of pancreatic neuroendocrine tumors (PNETs) is increasing. Its surgical indication depends on the risk of progression, whereas histological features can be assessed by endoscopic ultrasound\u2010guided fine\u2010needle biopsy (EUS\u2010FNB). However, its systematic use remains a matter of debate. We aimed to analyze the impact of EUS\u2010FNB on therapeutic management in patients with radiologically suspected PNETs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective observational single\u2010center study, all patients with suspected PNET by radiological imaging who underwent EUS\u2010FNB from 2011 to 2023 were enrolled. Patients with multiple endocrine neoplasia or previous\/metastatic tumors were excluded. The North American Neuroendocrine Tumor Society (NANETS) consensus was followed, and modifications in management due to FNB findings were detailed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 212 patients undergoing EUS\u2010FNB for suspected PNETs, 146 patients were included. No severe adverse events were reported during the biopsy procedure. Surgical pathology showed that the median tumor size was 17\u2009mm, 32.2% were located in the pancreatic head. Therapeutic management was modified in 12 (8.2%) patients based on EUS\u2010FNB findings due to different tumor types or additional high\u2010risk tumor feature (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095), different tumor grading (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094), and absence of malignancy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Systematic EUS\u2010FNB improves accuracy in PNET diagnosis and is associated with a non\u2010negligible rate of change in management. Large\u2010scale studies are needed to confirm our findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1751-2980.70069","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:48:35Z","timestamp":1788421715000},"page":"334-341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Impact of Endoscopic Ultrasound\u2010Guided Fine\u2010Needle Biopsy in Radiologically Suspected Pancreatic Neuroendocrine Tumors"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1810-6973","authenticated-orcid":false,"given":"Carolina","family":"Gonz\u00e1lez\u2010Ab\u00f3s","sequence":"first","affiliation":[{"name":"Department of HBP and Transplant Surgery Hospital Cl\u00ednic de Barcelona  Barcelona Spain"},{"name":"University of Barcelona  Barcelona Spain"},{"name":"Gene Therapy and Cancer, IDIBAPS  Barcelona 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