{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:05:02Z","timestamp":1790762702640,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470583"],"award-info":[{"award-number":["82470583"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473582"],"award-info":[{"award-number":["82473582"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Hepatic encephalopathy (HE) is one of the common complications of cirrhosis. Gut\u2010derived signals, including microbiota and bile acids, have been found to be involved in the gut\u2013brain axis in cirrhosis. We aimed to explore the impact of the gut\u2010microbiota\u2010bile acid axis on behavioral deficits in cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Mice were colonized with gut bacteria obtained from cirrhotic patients with or without HE via fecal microbiota transplantation. Serum bile acid profiles, intestinal histological features, and behaviors were assessed to evaluate the impacts of gut microbial disturbance on bile acids and gut\u2010brain axis. Additionally, rodent cirrhotic models were induced by bile duct ligation (BDL), and the mice were treated with obeticholic acid (OCA) or rifaximin to evaluate the impact of bile acid remodeling on gut bacteria, gut injury, and behaviors. The 16S rRNA sequencing and LC\u2010MS\/MS were carried out to analyze gut microbiota composition and bile acid spectrum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Gut bacteria transplanted from cirrhotic patients caused reduced levels of total and secondary bile acids in mice, which was accompanied by increased colonic lymphocytic infiltration, decreased exploratory behaviors, and higher expression of IBA\u20101. OCA intervention improved\u00a0gut dysbiosis, alleviated liver injury and exploratory behavior impairment in the cirrhotic mouse model, accompanied by increased Farnesoid X receptor (FXR) expression and decreased ASBT, IBABP, and OST\u03b1 levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Gut microbiota\u2010bile acid axis correlates with colonic inflammation and behavioral deficits in cirrhosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1751-2980.70072","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:38:08Z","timestamp":1790761088000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut Microbiota\u2010Bile Acid Axis Correlates With Colonic Inflammation and Behavioral Deficits in Cirrhosis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8569-3330","authenticated-orcid":false,"given":"Li Juan","family":"Sun","sequence":"first","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University  Xi'an Shaanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8627-0049","authenticated-orcid":false,"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cancer Biology &amp; Institute of Digestive Diseases Xijing Hospital, The Fourth Military Medical University  Xi'an Shaanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Jing","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University  Xi'an Shaanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi Yi","family":"Shi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University  Xi'an Shaanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9708-462X","authenticated-orcid":false,"given":"Yuan Jie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University  Xi'an Shaanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University  Xi'an Shaanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1124-4548","authenticated-orcid":false,"given":"Yong Zhan","family":"Nie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cancer Biology &amp; Institute of Digestive Diseases Xijing Hospital, The Fourth Military Medical University  Xi'an Shaanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"issue":"10258","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global Burden of 369 Diseases and Injuries in 204 Countries and Territories, 1990\u20132019: A Systematic Analysis for the Global Burden of Disease Study 2019","volume":"396","author":"GBD 2019 Diseases and Injuries Collaborators","year":"2020","journal-title":"Lancet"},{"issue":"2","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/hep.27210","article-title":"Hepatic Encephalopathy in Chronic Liver Disease: 2014 Practice Guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver","volume":"60","author":"Vilstrup H.","year":"2014","journal-title":"Hepatology"},{"issue":"1","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1016\/j.jhep.2020.11.013","article-title":"The Microbiota in Cirrhosis and Its Role in Hepatic Decompensation","volume":"75","author":"Trebicka J.","year":"2021","journal-title":"Journal of Hepatology"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26020527"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1337889"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010025\u201006774\u2010y"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-med-042320-014032","article-title":"The Gut\u2010Brain Axis","volume":"73","author":"Mayer E. 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