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Some\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    species, most commonly\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    , may lead to a variety of allergic reactions and life\u2010threatening systemic infections in humans. Invasive aspergillosis occurs primarily in patients with severe immunodeficiency, and has dramatically increased in recent years. There are several factors at play that contribute to aspergillosis, including both fungus and host\u2010related factors such as strain virulence and host pulmonary structure\/immune status, respectively. The environmental tenacity of\n                    <jats:italic>Aspergilllus<\/jats:italic>\n                    , its dominance in diverse microbial communities\/habitats, and its ability to navigate the ecophysiological and biophysical challenges of host infection are attributable, in large part, to a robust stress\u2010tolerance biology and exceptional capacity to generate cell\u2010available energy. Aspects of its stress metabolism, ecology, interactions with diverse animal hosts, clinical presentations and treatment regimens have been well\u2010studied over the past years. Here, we synthesize these findings in relation to the way in which some\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    species have become successful opportunistic pathogens of human\u2010 and other animal hosts. We focus on the biophysical capabilities of\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    pathogens, key aspects of their ecophysiology and the flexibility to undergo a sexual cycle or form cryptic species. Additionally, recent advances in diagnosis of the disease are discussed as well as implications in relation to questions that have yet to be resolved.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.12367","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T10:30:10Z","timestamp":1465295410000},"page":"296-322","source":"Crossref","is-referenced-by-count":326,"title":["Ecology of aspergillosis: insights into the pathogenic potency of\n                    <i>Aspergillus fumigatus<\/i>\n                    and some other\n                    <i>Aspergillus<\/i>\n                    species"],"prefix":"10.1111","volume":"10","author":[{"given":"Caroline","family":"Paulussen","sequence":"first","affiliation":[{"name":"Laboratory for Process Microbial Ecology and Bioinspirational Management (PME&amp;BIM) Department of Microbial and Molecular Systems (M2S) KU Leuven Campus De Nayer Sint\u2010Katelijne\u2010Waver B\u20102860 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Hallsworth","sequence":"additional","affiliation":[{"name":"Institute for Global Food Security School of Biological Sciences Medical Biology Centre Queen's University Belfast Belfast BT9 7BL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"\u00c1lvarez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Department of Animal Health Universidad Complutense de Madrid Madrid E\u201028040 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Nierman","sequence":"additional","affiliation":[{"name":"Infectious Diseases Program J. Craig Venter Institute La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip G.","family":"Hamill","sequence":"additional","affiliation":[{"name":"Institute for Global Food Security School of Biological Sciences Medical Biology Centre Queen's University Belfast Belfast BT9 7BL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Blain","sequence":"additional","affiliation":[{"name":"Institute for Global Food Security School of Biological Sciences Medical Biology Centre Queen's University Belfast Belfast BT9 7BL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Rediers","sequence":"additional","affiliation":[{"name":"Laboratory for Process Microbial Ecology and Bioinspirational Management (PME&amp;BIM) Department of Microbial and Molecular Systems (M2S) KU Leuven Campus De Nayer Sint\u2010Katelijne\u2010Waver B\u20102860 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