{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T19:19:19Z","timestamp":1787426359209,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T00:00:00Z","timestamp":1516147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01KI1313C"],"award-info":[{"award-number":["01KI1313C"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Biotechnology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    High prevalence numbers of extended\u2010spectrum beta\u2010lactamase\u2010 (\n                    <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content>\n                    \u2010)\/plasmid\u2010mediated AmpC beta\u2010lactamase\u2010 (\n                    <jats:styled-content style=\"fixed-case\">pA<\/jats:styled-content>\n                    mpC\u2010) producing\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    in broiler chicken and their distribution along the broiler production chain is an ongoing problem in food production. We, therefore, investigated resistant isolates along the broiler production chain to determine whether there is a constantly occurring direct vertical transmission of the\n                    <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content>\n                    \u2010\/\n                    <jats:styled-content style=\"fixed-case\">pA<\/jats:styled-content>\n                    mpC\u2010producing\n                    <jats:italic>E.\u00a0coli<\/jats:italic>\n                    from the parent flocks to their offspring or not. We, furthermore, analysed the isolates concerning the occurrence of virulence factors and their ability to form biofilms to estimate their potential to effectively colonize broiler chickens and\/or persist and survive in the environment of the broiler production facilities. Using whole genome sequencing, we could show that\n                    <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content>\n                    \u2010\/\n                    <jats:styled-content style=\"fixed-case\">pA<\/jats:styled-content>\n                    mpC\u2010producing\n                    <jats:italic>E.\u00a0coli<\/jats:italic>\n                    were likely transferred in a step\u2010wise process along the broiler production chain but not directly from the parent flock to the fattening flock with every single batch of offspring chickens. Additionally, resistant\n                    <jats:italic>E.\u00a0coli<\/jats:italic>\n                    strains showing an extraintestinal pathogenic genotype as well as high numbers of virulence\u2010associated genes including the production of curli fibres and cellulose have high capabilities to persist and spread in the broiler production chain.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.13040","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T22:36:47Z","timestamp":1516228607000},"page":"1017-1026","source":"Crossref","is-referenced-by-count":42,"title":["Environmental adaptation and vertical dissemination of\n                    <scp>ESBL<\/scp>\n                    \u2010\/\n                    <scp>pA<\/scp>\n                    mpC\u2010producing\n                    <i>Escherichia coli<\/i>\n                    in an integrated broiler production chain in the absence of an antibiotic 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