{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T09:58:22Z","timestamp":1762250302935,"version":"build-2065373602"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundamental Research Funds for the Central Universities, China","award":["KYZ201722"],"award-info":[{"award-number":["KYZ201722"]}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbial Biotechnology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    We previously reported that protein\u2010restricted rats experienced compensatory growth when they were switched to a normal protein diet (\n                    <jats:styled-content style=\"fixed-case\">NPD<\/jats:styled-content>\n                    ). This study aimed to investigate the changes in gene expression and microbiome in the jejunum of compensatory\u2010growth rats. Weaned Sprague\u2010Dawley rats were assigned to an N group, an\n                    <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>\n                    group and an L group. The rats in the L and N groups were fed a low protein diet (\n                    <jats:styled-content style=\"fixed-case\">LPD<\/jats:styled-content>\n                    ) and the\n                    <jats:styled-content style=\"fixed-case\">NPD<\/jats:styled-content>\n                    respectively. The rats in the\n                    <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>\n                    group were fed with the\n                    <jats:styled-content style=\"fixed-case\">LPD<\/jats:styled-content>\n                    for 2\u00a0weeks, followed by the\n                    <jats:styled-content style=\"fixed-case\">NPD<\/jats:styled-content>\n                    . The experiment lasted 70\u00a0days, and the rats were sacrificed for sampling on days 14, 28 and 70 to determine the jejunal morphology, microbiome and gene expression related to digestive, absorptive and barrier function. The results showed that, although rats in the\n                    <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>\n                    group had temporarily impaired morphology and gene expression in the jejunum on day 14 in response to the\n                    <jats:styled-content style=\"fixed-case\">LPD<\/jats:styled-content>\n                    , they had improved jejunal morphology and gene expression related to jejunal function on day 28 compared to rats in the N group. This improvement might promote compensatory growth of rats. However, lower expression of genes related to nutrient absorption and undifferentiated villous height (\n                    <jats:styled-content style=\"fixed-case\">VH<\/jats:styled-content>\n                    ) were observed in the jejunum of rats in the\n                    <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>\n                    group on day 70. In contrast, rats in the L group had lower\n                    <jats:styled-content style=\"fixed-case\">VH<\/jats:styled-content>\n                    on day 28 and day 70, while the expression of absorptive genes increased on day 28 compared to rats in the N group. Additionally, dramatic microbial changes in the jejunum of compensatory\u2010growth rats were observed, principally for\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    ,\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    ,\n                    <jats:italic>Corynebacterium<\/jats:italic>\n                    and\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    . Moreover, the abundance of\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    ,\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    ,\n                    <jats:italic>Corynebacterium<\/jats:italic>\n                    and\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    significantly correlated with gene expression in the jejunum as revealed by the correlation analysis.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.13266","type":"journal-article","created":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T20:46:37Z","timestamp":1523306797000},"page":"734-746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Dynamic changes in morphology, gene expression and microbiome in the jejunum of compensatory\u2010growth rats induced by protein 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