{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:45:42Z","timestamp":1778931942134,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31501962"],"award-info":[{"award-number":["31501962"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbial Biotechnology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Short\u2010chain fatty acids (\n                    <jats:styled-content style=\"fixed-case\">SCFA<\/jats:styled-content>\n                    s), particularly butyrate, are known to suppress inflammation, and regulate the gut bacterial ecology. However, little is known about propionate. We report here that propionate infusion in the caecum dramatically affected the structure of colonic microbiota of pigs based on 16s\n                    <jats:styled-content style=\"fixed-case\">rRNA<\/jats:styled-content>\n                    high\u2010throughput sequencing. Sixteen pig models were perfused with saline or sodium propionate by a fistula in the caecum. At d 28, all pigs were slaughtered for analysing bacterial metabolites, colonic microbiota and the expression of genes related to inflammation. The results showed that caecal infusion of sodium propionate increased the concentration of propionate and decreased the butyrate concentration in colonic content. For biogenic amines, the tyramine concentration was increased, while the concentration of cadaverine was decreased by infusion of sodium propionate. Furthermore, at the level of phylum, propionate increased the abundance of\n                    <jats:italic>Bacteroidetes<\/jats:italic>\n                    and reduced the abundance of\n                    <jats:italic>Firmicutes<\/jats:italic>\n                    .\n                    <jats:italic>Prevotella<\/jats:italic>\n                    and\n                    <jats:italic>Bacteroides<\/jats:italic>\n                    counts were\u00a0increased, while\n                    <jats:italic>Turicibacter<\/jats:italic>\n                    abundance was decreased at the level of genus. Real\u2010time\n                    <jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content>\n                    showed that the expression of\n                    <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\n                    \u2010\u03baB and\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201018 was upregulated by propionate infusion, whereas no significant differences were observed for the expression of other genes related to inflammatory processes. Taken together, these results provide a new evidence for the role of short\u2010chain fatty acid propionate on the composition of microbial community and inflammatory cytokines.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.13282","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T06:55:55Z","timestamp":1527836155000},"page":"859-868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Caecal infusion of the short\u2010chain fatty acid propionate affects the microbiota and expression of inflammatory cytokines in the colon in a fistula pig model"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4828-8130","authenticated-orcid":false,"given":"Yanan","family":"Zhang","sequence":"first","affiliation":[{"name":"Laboratory of Gastrointestinal Microbiology Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health College of Animal Science and Technology Nanjing Agricultural University Nanjing 210095 China"},{"name":"National Center for International Research on Animal Gut Nutrition Nanjing Agricultural University Nanjing 210095 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5018-3744","authenticated-orcid":false,"given":"Kaifan","family":"Yu","sequence":"additional","affiliation":[{"name":"Laboratory of Gastrointestinal Microbiology Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health College of Animal Science and Technology Nanjing Agricultural University Nanjing 210095 China"},{"name":"National Center for International Research on Animal Gut Nutrition Nanjing Agricultural University Nanjing 210095 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huizi","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Gastrointestinal Microbiology Jiangsu Key Laboratory of Gastrointestinal Nutrition and 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