{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T17:04:20Z","timestamp":1775754260169,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T00:00:00Z","timestamp":1537142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2014A030306015"],"award-info":[{"award-number":["2014A030306015"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571969"],"award-info":[{"award-number":["31571969"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbial Biotechnology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Clinical treatment of\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    infections has become more difficult due to the limited development of antifungal agents and the rapid emergence of drug resistance. In this study, we demonstrate the synthesis of a series of piperazine derivatives and the evaluation of their inhibitory activity against\n                    <jats:italic>C.\u00a0albicans<\/jats:italic>\n                    virulence. Thirty\u2010four (1\u2010aryloxy\u20102\u2010hydroxypropyl)\u2010phenylpiperazine derivatives, including 25 new compounds, were synthesized and assessed for their efficacy against the physiology and pathogenesis of\n                    <jats:italic>C.\u00a0albicans<\/jats:italic>\n                    . Several compounds strongly inhibited the morphological transition and virulence of\n                    <jats:italic>C.\u00a0albicans<\/jats:italic>\n                    cells, although they did not influence the growth rate of the fungal pathogen. A leading novel compound, (1\u2010(4\u2010ethoxyphenyl)\u20104\u2010(1\u2010biphenylol\u20102\u2010hydroxypropyl)\u2010piperazine), significantly attenuated\n                    <jats:italic>C.\u00a0albicans<\/jats:italic>\n                    virulence by interfering with the process of hyphal development, but it showed no cytotoxicity against human cells at a micromolar level. These findings suggest that (1\u2010aryloxy\u20102\u2010hydroxypropyl)\u2010phenylpiperazine derivatives could potentially be developed as novel therapeutic agents for the clinical treatment of\n                    <jats:italic>C.\u00a0albicans<\/jats:italic>\n                    infections by interfering with morphological transition and virulence.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.13307","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T03:53:30Z","timestamp":1537156410000},"page":"1080-1089","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["(1\u2010aryloxy\u20102\u2010hydroxypropyl)\u2010phenylpiperazine derivatives suppress\n                    <i>Candida albicans<\/i>\n                    virulence by interfering with morphological 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