{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:52:45Z","timestamp":1790837565219,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670495"],"award-info":[{"award-number":["81670495"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600417"],"award-info":[{"award-number":["81600417"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873548"],"award-info":[{"award-number":["81873548"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbial Biotechnology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The efficacy of faecal microbiota transplantation (FMT) in Crohn\u2019s disease (CD) remains unclear due to lack of data. This study aimed to assess the value of FMT in treating CD\u2010related clinical targets. The use of FMT for CD as a registered trial (NCT01793831) was performed between October 2012 and December 2017. Seven therapeutic targets included abdominal pain, diarrhoea, hematochezia, fever, steroid\u2010dependence, enterocutaneous fistula and active perianal fistula. Each target was recorded as 1 (yes) or 0 (no) during the long\u2010term follow\u2010up for each patient. The primary outcome was the rate of improvement in each therapeutic target. Overall, 174 patients completed the follow\u2010up. The median follow\u2010up duration was 43 (interquartile range, 28\u201359) months. The median score of the total targets was 2 (range, 1\u20134) before FMT, and it decreased significantly at 1, 3, 6, 12, 24 and 36\u00a0months after FMT (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.001 respectively). At 1\u00a0month after FMT, 72.7% (101\/139), 61.6% (90\/146), 76% (19\/25) and 70.6% (12\/17) of patients achieved improvement in abdominal pain, diarrhoea, hematochezia and fever respectively. Furthermore, 50% (10\/20) of steroid\u2010dependent patients achieved steroid\u2010free remission after FMT. The present findings indicate that it is important to understand the efficacy of FMT in CD as a targeted therapy, especially for abdominal pain, hematochezia, fever and diarrhoea.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.13536","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T17:48:27Z","timestamp":1579542507000},"page":"760-769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Efficacy of faecal microbiota transplantation in Crohn\u2019s disease: a new target treatment?"],"prefix":"10.1111","volume":"13","author":[{"given":"Liyuan","family":"Xiang","sequence":"first","affiliation":[{"name":"Medical Center for Digestive Diseases the Second Affiliated Hospital of Nanjing Medical University Nanjing 210011 China"},{"name":"Key Lab of Holistic Integrative Enterology Nanjing Medical University Nanjing 211100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Ding","sequence":"additional","affiliation":[{"name":"Medical Center for Digestive Diseases the Second Affiliated Hospital of Nanjing Medical University Nanjing 210011 China"},{"name":"Key Lab of Holistic Integrative Enterology Nanjing Medical University Nanjing 211100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Center for Digestive Diseases the Second Affiliated Hospital of Nanjing Medical University Nanjing 210011 China"},{"name":"Key Lab of Holistic Integrative Enterology Nanjing Medical University Nanjing 211100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Wu","sequence":"additional","affiliation":[{"name":"Medical Center for Digestive Diseases the Second Affiliated Hospital of Nanjing Medical University Nanjing 210011 China"},{"name":"Key Lab of Holistic Integrative Enterology Nanjing Medical University Nanjing 211100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Dai","sequence":"additional","affiliation":[{"name":"Medical Center for Digestive Diseases the Second Affiliated Hospital of Nanjing Medical University Nanjing 210011 China"},{"name":"Key Lab of Holistic Integrative Enterology Nanjing Medical University Nanjing 211100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyan","family":"Long","sequence":"additional","affiliation":[{"name":"Medical Center for Digestive Diseases the Second Affiliated Hospital of Nanjing Medical University Nanjing 210011 China"},{"name":"Key Lab of Holistic Integrative Enterology Nanjing Medical University Nanjing 211100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"He","sequence":"additional","affiliation":[{"name":"Medical Center for Digestive Diseases the Second Affiliated Hospital of Nanjing Medical University Nanjing 210011 China"},{"name":"Key Lab of Holistic Integrative Enterology Nanjing Medical University Nanjing 211100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bota","family":"Cui","sequence":"additional","affiliation":[{"name":"Medical Center for Digestive Diseases the Second Affiliated Hospital of Nanjing Medical University Nanjing 210011 China"},{"name":"Key Lab of Holistic Integrative Enterology Nanjing Medical University Nanjing 211100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4157-1144","authenticated-orcid":false,"given":"Faming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical Center for Digestive Diseases the Second Affiliated Hospital of Nanjing Medical University Nanjing 210011 China"},{"name":"Key Lab of Holistic Integrative Enterology Nanjing Medical University Nanjing 211100 China"},{"name":"Division of Microbiotherapy Sir Run Run Shaw Hospital Nanjing Medical University Nanjing 211166 China"},{"name":"National Clinical Research Center for Digestive Diseases Xi'an 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14030"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12727"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0646-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2016.1151608"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-019-00809-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjw169"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjw168"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.10.007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0815-0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619845986"},{"key":"e_1_2_8_12_1","first-page":"778","article-title":"Faecal microbiota composition associates with abdominal pain in the general population","volume":"67","author":"Hadizadeh F.","year":"2018","journal-title":"Gut"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04984-z"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000131"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.09.060"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30012-3"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-018-9447-x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-018-0766-2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9050447"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx048"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30182-4"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-105205"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.233"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.357"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13475"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000307"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31711-1"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000893"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-018-0800-3"},{"key":"e_1_2_8_30_1","first-page":"995","article-title":"Efficacy of exclusive enteral nutrition in complicated Crohn's disease","volume":"52","author":"Yang Q.","year":"2017","journal-title":"Scand J Gastroenterol"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i41.7213"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21491"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-018-0541-8"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-019-00684-8"}],"container-title":["Microbial Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-7915.13536","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1751-7915.13536","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-7915.13536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T14:08:43Z","timestamp":1762265323000},"score":1,"resource":{"primary":{"URL":"https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/10.1111\/1751-7915.13536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,20]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/1751-7915.13536"],"URL":"https:\/\/doi.org\/10.1111\/1751-7915.13536","archive":["Portico"],"relation":{},"ISSN":["1751-7915","1751-7915"],"issn-type":[{"value":"1751-7915","type":"print"},{"value":"1751-7915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,20]]},"assertion":[{"value":"2019-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}