{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:37:47Z","timestamp":1792154267033,"version":"4.4.0"},"reference-count":105,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T00:00:00Z","timestamp":1588464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008972","name":"Savannah River Operations Office, U.S. Department of Energy","doi-asserted-by":"publisher","award":["DE\u2010FC09\u201007SR22506"],"award-info":[{"award-number":["DE\u2010FC09\u201007SR22506"]}],"id":[{"id":"10.13039\/100008972","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbial Biotechnology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Contaminants such as heavy metals may contribute to the dissemination of antimicrobial resistance (AMR) by enriching resistance gene determinants via co\u2010selection mechanisms. In the present study, a survey was performed on soils collected from four areas at the Savannah River Site (SRS), South Carolina, USA, with varying contaminant profiles: relatively pristine (Upper Three Runs), heavy metals (Ash Basins), radionuclides (Pond B) and heavy metal and radionuclides (Tim\u2019s Branch). Using 16S rRNA gene amplicon sequencing, we explored the structure and diversity of soil bacterial communities. Sites with legacies of metal and\/or radionuclide contamination displayed significantly lower bacterial diversity compared to the reference site. Metagenomic analysis indicated that multidrug and vancomycin antibiotic resistance genes (ARGs) and metal resistance genes (MRGs) including those associated with copper, arsenic, iron, nickel and zinc were prominent in all soils including the reference site. However, significant differences were found in the relative abundance and diversity of certain ARGs and MRGs in soils with metal\/radionuclide contaminated soils compared to the reference site. Co\u2010occurrence patterns revealed significant ARG\/MRG subtypes in predominant soil taxa including\n                    <jats:italic>Acidobacteriaceae<\/jats:italic>\n                    ,\n                    <jats:italic>Bradyrhizobium<\/jats:italic>\n                    ,\n                    <jats:italic>Mycobacterium<\/jats:italic>\n                    ,\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    ,\n                    <jats:italic>Verrumicrobium<\/jats:italic>\n                    ,\n                    <jats:italic>Actinomadura<\/jats:italic>\n                    and Solirubacterales. Overall, the study emphasizes the potential risk of human activities on the dissemination of AMR in the environment.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.13578","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T01:12:03Z","timestamp":1588554723000},"page":"1179-1200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":145,"title":["Co\u2010occurrence of antibiotic, biocide, and heavy metal resistance genes in bacteria from metal and radionuclide contaminated soils at the Savannah River Site"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9618-4662","authenticated-orcid":false,"suffix":"IV","given":"Jesse C.","family":"Thomas","sequence":"first","affiliation":[{"name":"Department of Environmental Health Science University of Georgia Athens GA 30602 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