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The previous study revealed that quinone compounds showed antimicrobial activity against\n                    <jats:italic>C. albicans<\/jats:italic>\n                    by inhibiting cell growth. However, it was unclear whether quinones have other antifungal effects against\n                    <jats:italic>C. albicans<\/jats:italic>\n                    in addition to fungicidal effects. In this study, we assessed the inhibitory activity of a total of 25 quinone compounds against\n                    <jats:italic>C. albicans<\/jats:italic>\n                    morphological transition, which is essential for the pathogenicity of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    . Several quinones exhibited strong inhibition of mycelium formation by\n                    <jats:italic>C. albicans<\/jats:italic>\n                    SC5314. Three leading compounds, namely hypocrellins A, B and C, also exhibited marked attenuation of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    SC5314 virulence in both human cell lines and mouse infection models. These three compounds significantly suppressed the proliferation of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    SC5314 cells in a mouse mucosal infection model. Intriguingly, hypocrellins not only attenuated the cytotoxicity of a nystatin\u2010resistant\n                    <jats:italic>C. albicans<\/jats:italic>\n                    strain but also showed excellent synergistic effects with antifungal agents against both wild\u2010type\n                    <jats:italic>C. albicans<\/jats:italic>\n                    SC5314 and the drug\u2010resistant mutant strains. In addition, hypocrellins A, B and C interfered with the biological functions and virulence of various clinical\n                    <jats:italic>Candida<\/jats:italic>\n                    species, suggesting the promising potential of these compounds for development as new therapeutic agents against infections caused by\n                    <jats:italic>Candida<\/jats:italic>\n                    pathogens.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.13601","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T10:12:28Z","timestamp":1591611148000},"page":"430-443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Antifungal activity of hypocrellin compounds and their synergistic effects with antimicrobial agents against\n                    <i>Candida albicans<\/i>"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0258-4065","authenticated-orcid":false,"given":"Shihao","family":"Song","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen) Sun Yat\u2010sen University Guangzhou 510275 China"},{"name":"College of Agriculture South China Agricultural University Guangzhou 510642 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyun","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Agriculture South China Agricultural University Guangzhou 510642 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Meng","sequence":"additional","affiliation":[{"name":"College of Agriculture South China Agricultural University Guangzhou 510642 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhua","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Agriculture South China Agricultural University Guangzhou 510642 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Medicine Ward The First Affiliated Hospital of Guangxi Medical University Nanning 530021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-0870","authenticated-orcid":false,"given":"Yinyue","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen) Sun Yat\u2010sen University Guangzhou 510275 China"},{"name":"College of Agriculture South China Agricultural University Guangzhou 510642 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