{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T01:44:54Z","timestamp":1772588694117,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T00:00:00Z","timestamp":1616803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbial Biotechnology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Infection by\n                    <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n                    has been identified as a preceding factor of Guillain\u2013Barr\u00e9\u2013Stohl syndrome. The Guillain\u2013Barr\u00e9\u2013Stohl syndrome is triggered by an immune reaction against the major glycolipids and it has been postulated that\n                    <jats:italic>M. pneumoniae<\/jats:italic>\n                    infection triggers this syndrome due to bacterial production of galactocerebroside. Here, we present an extensive comparison of 224 genome sequences from 104\n                    <jats:italic>Mycoplasma<\/jats:italic>\n                    species to characterize the genetic determinants of galactocerebroside biosynthesis. Hidden Markov models were used to analyse glycosil transferases, leading to identification of a functional protein domain, termed M2000535 that appears in about a third of the studied genomes. This domain appears to be associated with a potential UDP\u2010glucose epimerase, which converts UDP\u2010glucose into UDP\u2010galactose, a main substrate for the biosynthesis of galactocerebroside. These findings clarify the pathogenic mechanisms underlining the triggering of Guillain\u2013Barr\u00e9\u2013Stohl syndrome by\n                    <jats:italic>M<\/jats:italic>\n                    .\u00a0\n                    <jats:italic>pneumoniae<\/jats:italic>\n                    infections.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.13794","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T05:46:11Z","timestamp":1616823971000},"page":"1201-1211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Galactocerebroside biosynthesis pathways of\n                    <i>Mycoplasma<\/i>\n                    species: an antigen triggering Guillain\u2013Barr\u00e9\u2013Stohl syndrome"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3354-9721","authenticated-orcid":false,"given":"Erika","family":"Gaspari","sequence":"first","affiliation":[{"name":"Laboratory of Systems and Synthetic Biology Wageningen University &amp; Research Wageningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8172-8981","authenticated-orcid":false,"given":"Jasper J.","family":"Koehorst","sequence":"additional","affiliation":[{"name":"Laboratory of Systems and Synthetic Biology Wageningen University &amp; Research Wageningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9133-0280","authenticated-orcid":false,"given":"Joachim","family":"Frey","sequence":"additional","affiliation":[{"name":"Vetsuisse University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2352-9017","authenticated-orcid":false,"given":"Vitor A.P.","family":"Martins dos Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Systems and Synthetic Biology Wageningen University &amp; Research Wageningen the Netherlands"},{"name":"LifeGlimmer GmbH Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5845-146X","authenticated-orcid":false,"given":"Maria","family":"Suarez\u2010Diez","sequence":"additional","affiliation":[{"name":"Laboratory of Systems and Synthetic Biology Wageningen University &amp; Research Wageningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.214148"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(02)00209-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146377"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2007.06.017"},{"key":"e_1_2_9_6_1","first-page":"1188","volume-title":"WebLogo\u202f: A Sequence Logo Generator","author":"Crooks G. 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