{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:03:06Z","timestamp":1783609386579,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbial Biotechnology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Antibiotic resistance in\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    has been growing worldwide with current treatment regimens. Development of new compounds for treatment of\n                    <jats:italic>H.\u2009pylori<\/jats:italic>\n                    infections is urgently required to achieve a successful eradication therapy in the future. Armeniaspirols, a novel class of natural products isolated from\n                    <jats:italic>Streptomyces armeniacus<\/jats:italic>\n                    , have been previously identified as antibacterial agents against Gram\u2010positive pathogens. In this study, we found that armeniaspirol A (ARM1) exhibited potent antibacterial activity against\n                    <jats:italic>H.\u2009pylori<\/jats:italic>\n                    , including multidrug\u2010resistant strains, with MIC range values of 4\u201316\u2009\u03bcg\u2009ml\n                    <jats:sup>\u20101<\/jats:sup>\n                    . The underlying mechanism of action of\u00a0ARM1 against\n                    <jats:italic>H.\u2009pylori<\/jats:italic>\n                    involved the disruption of bacterial cell membranes. Also, ARM1 inhibited biofilm formation, eliminated preformed biofilms and killed biofilm\u2010encased\n                    <jats:italic>H.\u2009pylori<\/jats:italic>\n                    in a dose\u2010dependent manner. In a mouse model of multidrug\u2010resistant\n                    <jats:italic>H.\u2009pylori<\/jats:italic>\n                    infection, dual therapy with ARM1 and omeprazole showed efficient\n                    <jats:italic>in\u00a0vivo<\/jats:italic>\n                    killing efficacy comparable to the standard triple therapy, and induced negligible toxicity against normal tissues. Moreover, at acidic pH 2.5, ARM1 exhibited a much more potent anti\u2010\n                    <jats:italic>H.\u2009pylori<\/jats:italic>\n                    activity than metronidazole. Thus, these findings demonstrated that ARM1 is a novel potent anti\u2010\n                    <jats:italic>H.\u2009pylori<\/jats:italic>\n                    agent, which can be developed as a promising drug lead for treatment of\n                    <jats:italic>H.\u2009pylori<\/jats:italic>\n                    infections.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.13807","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T10:10:42Z","timestamp":1617012642000},"page":"442-454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Armeniaspirol A: a novel anti\u2010\n                    <i>Helicobacter pylori<\/i>\n                    agent"],"prefix":"10.1111","volume":"15","author":[{"given":"Jia","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Pathogen Biology &amp; Jiangsu Key Laboratory of Pathogen Biology &amp; Helicobacter pylori Research 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