{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:57:20Z","timestamp":1792069040379,"version":"4.4.0"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31630075"],"award-info":[{"award-number":["31630075"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32002185"],"award-info":[{"award-number":["32002185"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbial Biotechnology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Faecal Microbiota Transplantation (FMT) is considered as a promising technology to fight against obesity. Wild boar has leanermuscle and less fat in comparison to the domestic pig, which were thought to be related with microbiota. To investigate the function and mechanism of the wild boar microbiota on obesity, we first analysed the wild boar microbiota composition via 16S rDNA sequencing, which showed that Firmicutes and Proteobacteria were the dominant bacteria. Then, we established a high\u2010fat diet (HFD)\u2010induced obesity model, and transfer low and high concentrations of wild boar faecal suspension in mice for 9\u2009weeks. The results showed that FMT prevented HFD\u2010induced obesity and lipid metabolism disorders, and altered the jejunal microbiota composition especially increasing the abundance of the\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    and\n                    <jats:italic>Romboutsia<\/jats:italic>\n                    , which were negatively correlated with obesity\u2010related indicators. Moreover, we found that the anti\u2010obesity effect of wild boar faecal suspension was associated with jejunal N6\u2010methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) levels. Overall, these results suggest that FMT has a mitigating effect on HFD\u2010induced obesity, which may be due to the impressive effects of FMT on the microbial composition and structure of the jejunum. These changes further alter intestinal lipid metabolism and m\n                    <jats:sup>6<\/jats:sup>\n                    A levels to achieve resistance to obesity.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.13951","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T03:43:17Z","timestamp":1635306197000},"page":"337-352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Faecal microbiota transplantation\u2010mediated jejunal microbiota changes halt high\u2010fat diet\u2010induced obesity in mice via retarding intestinal fat absorption"],"prefix":"10.1111","volume":"15","author":[{"given":"Luoyi","family":"Zhu","sequence":"first","affiliation":[{"name":"National Engineering Laboratory for Feed Safety and Pollution Prevention and Controlling National Development and Reform Commission Hangzhou Zhejiang 310058 China"},{"name":"Key Laboratory of Molecular Animal 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